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Table 4 Hazard ratios for composite of ESRD or death associated with BUN and cSosm levels (sensitivity analysis)

From: Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3–5 chronic kidney disease: a prospective observational study

 

Analysis 1

HR

95% CI

P

P for trend

BUN

 Q1

reference

< 0.01

 Q2

1.86

1.01–3.40

0.045

 Q3

2.66

1.44–4.89

< 0.01

 Q4

3.11

1.50–6.46

< 0.01

cSosm

 Q1

reference

0.42

 Q2

1.12

0.68–1.85

0.66

 Q3

1.03

0.63–1.69

0.90

 Q4

1.24

0.75–2.04

0.40

  1. Analysis 1: adjusted for age; sex; diabetes mellitus; smoking; systolic blood pressure; dyslipidemia; use of immunosuppressants, and diuretics; C-reactive protein; body mass index; daily proteinuria; hemoglobin; serum creatinine; serum phosphorus; and serum albumin
  2. ESRD end-stage renal disease, BUN blood urea nitrogen, cSosm calculated serum osmolality, HR hazard ratio, CI confidence interval
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