IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney

BMC Nephrology

Table 2 The associations between histopathological changes (i, t, v, ah, ci, cg, ct, cv, mm) in kidney allografts and rs2275913 IL17A gene polymorphism

Biopsy parameter and genotypes	Grade 0 n %		Grade 1 n %		Grade 2 n %		Grade 3 n %		Mean ± SD	M-W test p for comparison
										GGvsAG+AA	AAvsAG+GG
(i) n = 72
AA	2	20.00	4	40.00	2	20.00	2	20.00	1.40 ± 1.08
AG	9	26.47	13	38.24	7	20.59	5	14.71	1.24 ± 1.02	0.96	0.68
GG	9	32.14	8	28.57	5	17.86	6	21.43	1.29 ± 1.15
(t) n = 64
AA	1	11.11	4	44.44	1	11.11	3	33.33	1.67 ± 1.12
AG	5	17.24	13	44.83	9	31.03	2	6.90	1.28 ± 0.84	0.02	0.13
GG	11	42.31	10	38.46	3	11.54	2	7.69	0.85 ± 0.92
(v) n = 57
AA	6	85.71	1	14.29	0	0.00	0	0.00	0.14 ± 0.38
AG	25	89.29	1	3.57	1	3.57	1	3.57	0.21 ± 0.69	0.37	0.64
GG	21	95.45	1	4.55	0	0.00	0	0.00	0.05 ± 0.21
(ah) n = 68
AA	6	66.67	3	33.33	0	0.00	0	0.00	0.33 ± 0.50
AG	8	25.00	17	53.13	7	21.87	0	0.00	0.97 ± 0.70	0.45	0.01
GG	8	29.63	12	44.44	6	22.22	1	3.70	1.00 ± 0.83
(ci) n = 68
AA	6	60.00	4	40.00	0	0.00	0	0.00	0.40 ± 0.52
AG	16	50.00	10	31.25	5	15.63	1	3.13	0.72 ± 0.85	0.61	0.32
GG	13	50.00	7	26.92	4	15.38	2	7.69	0.81 ± 0.98
(cg) n = 55
AA	7	100.0	0	0.00	–		0	0.00	0.00 ± 0.00
AG	22	91.67	1	4.17	–		1	4.17	0.17 ± 0.64	0.14	0.29
GG	19	79.17	5	20.83	–		0	0.00	0.21 ± 0.42
(ct) n = 68
AA	3	30.00	6	60.00	0	0.00	1	10.00	0.90 ± 0.88
AG	2	6.25	20	62.50	8	25.00	2	6.25	1.31 ± 0.69	0.97	0.11
GG	5	19.23	13	50.00	5	19.23	3	11.54	1.23 ± 0.91
(cv) n = 51
AA	6	75.00	1	12.50	0	00.00	1	12.50	0.50 ± 1.07
AG	14	56.00	2	8.00	4	16.00	5	20.00	1.00 ± 1.26	0.79	0.38
GG	11	61.11	3	16.67	2	11.11	2	11.11	0.72 ± 1.07
(mm) n = 60
AA	7	87.50	1	12.50	0	0.00	0	0.00	0.13 ± 0.35
AG	14	51.85	7	25.93	2	7.41	4	14.81	0.85 ± 1.10	0.39	0.04
GG	12	48.00	7	28.00	3	12.00	3	12.00	0.88 ± 1.05

p value calculated with the Mann-Whitney’s (M-W) test
i – interstitial infiltration, t – tubulitis, v – intimal arteritis, ah – arteriolar hyaline thickening, ci – interstitial fibrosis, cg – glomerulopathy, ct – tubular atrophy, cv – fibrous intimal thickening, mm – mesangial matrix increase

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