IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney

BMC Nephrology

Table 4 The associations between histopathological changes (i, t, v, ah, ci, cg, ct, cv, mm) in kidney allografts and rs11465553 IL17F gene polymorphism

Biopsy parameter and genotypes	Grade 0 n %		Grade 1 n %		Grade 2 n %		Grade 3 n %		Mean ± SD	M-W test p for comparison GGvsGA
(i) n = 72
GG	17	27.42	22	35.48	13	20.97	10	16.13	1.26 ± 1.04	0.79
GA	3	30.00	3	30.00	1	10.00	3	30.00	1.40 ± 1.27
(t) n = 64
GG	15	27.27	24	43.64	10	18.18	6	10.91	1.13 ± 0.94	0.51
GA	2	22.22	3	33.33	3	33.33	1	11.11	1.33 ± 1.00
(v) n = 57
GG	44	93.62	2	4.26	0	0.00	1	2.13	0.11 ± 0.48	0.18
GA	8	80.0	1	10.00	1	10.00	0	0.00	0.30 ± 0.68
(ah) n = 68
GG	20	33.90	27	45.76	11	18.64	1	1.69	0.88 ± 0.77	0.60
GA	2	22.22	5	55.56	2	22.22	0	0.00	1.00 ± 0.71
(ci) n = 68
GG	28	48.28	19	32.76	8	13.79	3	5.17	0.76 ± 0.89	0.21
GA	7	70.00	2	20.00	1	10.00	0	0.00	0.40 ± 0.70
(cg) n = 55
GG	40	85.11	6	12.77	–		1	2.13	0.19 ± 0.54	0.26
GA	8	100.0	0	0.00	–		0	0.00	0.00 ± 0.00
(ct) n = 68
GG	9	15.25	32	54.24	13	22.03	5	8.47	1.24 ± 0.82	0.56
GA	1	11.11	7	77.78	0	0.00	1	11.11	1.11 ± 0.78
(cv) n = 51
GG	29	64.44	6	13.33	4	18.89	6	13.33	0.71 ± 1.10	0.086
GA	2	33.33	0	0.00	2	33.33	2	33.33	1.67 ± 1.37
(mm) n = 60
GG	28	52.83	14	26.42	4	7.55	7	13.21	0.81 ± 1.06	0.36
GA	5	71.43	1	14.29	1	14.29	0	0.00	0.43 ± 0.79

p value calculated with the Mann-Whitney’s (M-W) test
i interstitial infiltration, t tubulitis, v intimal arteritis, ah arteriolar hyaline thickening, ci interstitial fibrosis, cg glomerulopathy, ct tubular atrophy, cv fibrous intimal thickening, mm mesangial matrix increase

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