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Fig. 1 | BMC Nephrology

Fig. 1

From: Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

Fig. 1

Assessment of Kidney injury. Panel a Urinary albumin to creatinine ratio (UACR) for WT and Meprin βKO mice, Panel b Urinary KIM-1 levels, and Panel c fold change in KIM-1. Spot urine samples were collected by bladder massage at 4 and 8 weeks post-STZ injection. ELISA kits (R&D Systems) were used for albumin and KIM-1 assays and calorimetric assays kits (Diazyme Inc) for creatinine assays. Urinary KIM-1 concentrations were normalized to urinary creatinine concentrations. The fold change in KIM-1/Creatinine ratio (panel B) were calculated relative to the concentrations in the control mice for each genotype. Data are represented as mean ± SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001

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