Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

Table 1 PCA/multivariate Analysis models for plasma

	Model	# of Compounds	Total # Samples	# of Components	R2X	R2Y	Q2	# Samples in STZ	# Samples in NaC
Positive	PCA All Samples	2414	62	7	0.947		0.85
	PCA 4 wks	2414	28	7	0.96		0.841
	PCA WT STZ v WT NaC 4 wk	2414	14	4	0.937		0.759
	OPLSDA WT STZ v WT NaC 4 wk	2414	14	1 + 1	0.75	0.619	0.0699	9	5
	PCA βKO STZ v βKO NaC 4wk	2414	14	4	0.93		0.756
	OPLSDA βKO STZ v βKO NaC 4wk	2414	14	1 + 3	0.908	0.956	0.788	8	6
	PCA 8 wks	2414	28	5	0.942		0.834
	PCA WT STZ v WT NaC 8 wk	2414	13	5	0.967		0.829
	OPLSDA WT STZ v WT NaC 8 wk	2414	13	1 + 2	0.845	0.912	0.764	8	5
	PCA βKO STZ v βKO NaC 8wk	2414	14	4	0.962		0.912
	OPLSDA βKO STZ v βKO NaC 8wk	2414	14	1 + 7	0.984	1	0.731	8	6
Negative	PCA All Samples	633	57	8	0.877		0.711
	PCA 4 wks	633	25	3	0.76		0.385
	PCA WT STZ v WT NaC 4 wk	633	12	4	0.925		0.558
	OPLSDA WT STZ v WT NaC 4 wk	633	12	1 + 2	0.873	0.962	0.876	7	5
	PCA βKO STZ v βKO NaC 4wk	633	13	2	0.58		0.23
	OPLSDA βKO STZ v βKO NaC 4wk	633	13	1 + 1	0.528	0.958	0.876	7	6
	PCA 8 wk	633	26	3	0.759		0.478
	PCA WT STZ v WT NaC 8 wk	633	12	3	0.866		0.497
	OPLSDA WT STZ v WT NaC 8 wk	633	12	1 + 2	0.861	0.973	0.907	7	5
	PCA βKO STZ v βKO NaC 8wk	633	14	3	0.759		0.174
	OPLSDA βKO STZ v βKO NaC 8wk	633	14	1 + 1	0.498	0.871	0.686	8	6

ISSN: 1471-2369