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Table 4 Summary of differentiating plasma metabolites at 4- and 8-weeks post STZ with a 2 ≤ FC and/or 2 ≤ VIP. A variable importance in projection (VIP) score 2 ≤ are considered to have strong predictive value. Meprin expression associated metabolites (in either WT or meprin βKO mice only)

From: Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

 

4 Weeks post STZ

8 weeks Post STX

Metabolite

VIP

P-value*

FC**

Metabolite

VIP

P-value*

FC**

WT Only

3-Methoxy-4-hydroxyphenylethyleneglycol sulfate

0.7

0.003

6.6

3-Methoxy-4-hydroxyphenylethyleneglycol sulfate

0.5

0.01

9.1

N-Heptanoylglycine

0.6

0.005

-5.2

3-Aminosalicylic acid

0.9

0.045

3.6

3-Methoxytyrosine

0.5

0.018

−3.8

LysoPC(16:1(9Z))

3

0.019

−3.6

7-Methoxy-5-prenyloxycoumarin

0.6

0.042

2

5-Acetyl-2,4-dimethyloxazole

0.4

0.003

3.1

    

Guanine

0.3

0.019

2.7

    

Taurocholic acid

3.2

0.019

2.5

    

9′-Carboxy-gamma-chromanol

0.5

0.019

2.5

    

Riboflavin

0.4

0.019

2.5

    

N-Acetylleucine

1

0.005

2.2

    

Indoxyl sulfate

5.3

0.003

2.1

    

2-Phenylglycine

0.3

0.003

2.1

    

N-Heptanoylglycine

0.2

0.03

−2.1

    

7-Methoxy-5-prenyloxycoumarin

0.4

0.019

2

βKO Only

Porric acid B

0.5

0.021

3.7

Isovalerylalanine

0.7

0.016

−2.5

3-Methoxy-4-hydroxyphenylethyleneglycol sulfate

1.7

0.047

3.3

    

L-Acetylcarnitine

1

0.021

3.1

    

D-1,5-Anhydrofructose

0.8

0.01

−3.1

    

Hexanoylcarnitine

0.5

0.042

−2.2

    

N-Acetylleucine

1

0.021

2

    

Tyrosyl-Valine

0.3

0.016

2

    
  1. p-value* : p-value for Exact Wilcoxon Rank Sum Test
  2. FC**: A positive or negative fold change indicates median of STZ > median of NaC