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Table 4 Summary of differentiating plasma metabolites at 4- and 8-weeks post STZ with a 2 ≤ FC and/or 2 ≤ VIP. A variable importance in projection (VIP) score 2 ≤ are considered to have strong predictive value. Meprin expression associated metabolites (in either WT or meprin βKO mice only)

From: Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

  4 Weeks post STZ 8 weeks Post STX
Metabolite VIP P-value* FC** Metabolite VIP P-value* FC**
WT Only 3-Methoxy-4-hydroxyphenylethyleneglycol sulfate 0.7 0.003 6.6 3-Methoxy-4-hydroxyphenylethyleneglycol sulfate 0.5 0.01 9.1
N-Heptanoylglycine 0.6 0.005 -5.2 3-Aminosalicylic acid 0.9 0.045 3.6
3-Methoxytyrosine 0.5 0.018 −3.8 LysoPC(16:1(9Z)) 3 0.019 −3.6
7-Methoxy-5-prenyloxycoumarin 0.6 0.042 2 5-Acetyl-2,4-dimethyloxazole 0.4 0.003 3.1
     Guanine 0.3 0.019 2.7
     Taurocholic acid 3.2 0.019 2.5
     9′-Carboxy-gamma-chromanol 0.5 0.019 2.5
     Riboflavin 0.4 0.019 2.5
     N-Acetylleucine 1 0.005 2.2
     Indoxyl sulfate 5.3 0.003 2.1
     2-Phenylglycine 0.3 0.003 2.1
     N-Heptanoylglycine 0.2 0.03 −2.1
     7-Methoxy-5-prenyloxycoumarin 0.4 0.019 2
βKO Only Porric acid B 0.5 0.021 3.7 Isovalerylalanine 0.7 0.016 −2.5
3-Methoxy-4-hydroxyphenylethyleneglycol sulfate 1.7 0.047 3.3     
L-Acetylcarnitine 1 0.021 3.1     
D-1,5-Anhydrofructose 0.8 0.01 −3.1     
Hexanoylcarnitine 0.5 0.042 −2.2     
N-Acetylleucine 1 0.021 2     
Tyrosyl-Valine 0.3 0.016 2     
  1. p-value* : p-value for Exact Wilcoxon Rank Sum Test
  2. FC**: A positive or negative fold change indicates median of STZ > median of NaC