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Table 5 Summary of differentiating plasma metabolites at 4- and 8-weeks post STZ with a 2 ≤ FC and/or 2 ≤ VIP. A variable importance in projection (VIP) score 2 ≤ are considered to have strong predictive value. Diabetes/STZ associated plasma metabolites independent of meprin β expression/deficiency (change in both WT and meprin βKO mice)

From: Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

4 Weeks post STZ 8 weeks post-STZ
  WT βKO   WT βKO
VIP P-value* FC** VIP P-value* FC**   VIP P-value* FC** VIP P-value* FC**
Cortisol 1.7 0.003 23.2 0.9 0.013 2.4 Indole-3-carboxilic acid-O-sulphate 0.5 0.003 6.2 0.1 0.01 935.1
Indole-3-carboxilic acid-O-sulphate 0.7 0.005 4.7 0.2 0.013 10.3 Equol 7-O-glucuronide 0.3 0.002 4.5 0.4 0.02 3.2
LysoPC(16:1(9Z)) 5.1 0.002 −4 4.8 0.026 −2.3 Cortisol 0.9 0.003 4.2 0.8 0.026 4.4
Fenoprofen glucuronide 0.7 0.005 3.4 1.4 0.013 3.9        
L-Carnitine 0.9 0.019 −3.3 1.2 0.01 −3.2 Fenoprofen glucuronide 0.7 0.003 3.6 0.8 0.01 3.1
APGPR Enterostatin 1.1 0.005 −3 1.5 0.013 −4 Tyrosyl-Valine 0.3 0.019 3.4 0.3 0.033 1.9
Hippuric acid 0.9 0.048 2.4 1.6 0.013 2.7 3-Methoxy-4-hydroxyphenylethyleneglycol sulfate 0.7 0.03 3.2 0.9 0.042 2.7
3,4-Dihydroxyphenylglycol O-sulfate 0.5 0.005 2.4 0.4 0.036 1.2 Hippuric acid 1.2 0.003 3.2 1.2 0.012 2.5
Isovalerylalanine 0.5 0.005 −2.3 0.8 0.013 −2.2        
  1. p-value* : p-value for Exact Wilcoxon Rank Sum Test
  2. FC**: A positive or negative fold change indicates median of STZ > median of NaC