Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

Table 5 Summary of differentiating plasma metabolites at 4- and 8-weeks post STZ with a 2 ≤ FC and/or 2 ≤ VIP. A variable importance in projection (VIP) score 2 ≤ are considered to have strong predictive value. Diabetes/STZ associated plasma metabolites independent of meprin β expression/deficiency (change in both WT and meprin βKO mice)

4 Weeks post STZ							8 weeks post-STZ
	WT			βKO				WT			βKO
	VIP	P-value*	FC**	VIP	P-value*	FC**		VIP	P-value*	FC**	VIP	P-value*	FC**
Cortisol	1.7	0.003	23.2	0.9	0.013	2.4	Indole-3-carboxilic acid-O-sulphate	0.5	0.003	6.2	0.1	0.01	935.1
Indole-3-carboxilic acid-O-sulphate	0.7	0.005	4.7	0.2	0.013	10.3	Equol 7-O-glucuronide	0.3	0.002	4.5	0.4	0.02	3.2
LysoPC(16:1(9Z))	5.1	0.002	−4	4.8	0.026	−2.3	Cortisol	0.9	0.003	4.2	0.8	0.026	4.4
Fenoprofen glucuronide	0.7	0.005	3.4	1.4	0.013	3.9
L-Carnitine	0.9	0.019	−3.3	1.2	0.01	−3.2	Fenoprofen glucuronide	0.7	0.003	3.6	0.8	0.01	3.1
APGPR Enterostatin	1.1	0.005	−3	1.5	0.013	−4	Tyrosyl-Valine	0.3	0.019	3.4	0.3	0.033	1.9
Hippuric acid	0.9	0.048	2.4	1.6	0.013	2.7	3-Methoxy-4-hydroxyphenylethyleneglycol sulfate	0.7	0.03	3.2	0.9	0.042	2.7
3,4-Dihydroxyphenylglycol O-sulfate	0.5	0.005	2.4	0.4	0.036	1.2	Hippuric acid	1.2	0.003	3.2	1.2	0.012	2.5
Isovalerylalanine	0.5	0.005	−2.3	0.8	0.013	−2.2

p-value* : p-value for Exact Wilcoxon Rank Sum Test
FC**: A positive or negative fold change indicates median of STZ > median of NaC

ISSN: 1471-2369