Table 6 Summary of differentiating urinary metabolites in WT and meprin βKO mice at 4- and 8-weeks post STZ with a 2 ≤ FC and/or 2 ≤ VIP. A variable importance in projection (VIP) score 2 ≤ are considered to have strong predictive value. Differentiating urinary metabolites that associate with meprin expression (Change in either WT or βKO only)
4 Weeks post STZ | 8 Weeks post STZ | |||||||
|---|---|---|---|---|---|---|---|---|
VIP | P-value* | FC** | VIP | P-value* | FC** | |||
WT Only | Cortisol | 10.5 | 0.003 | 54.9 | Cortisol | 8.2 | 0.002 | 21.6 |
9,13-Dihydroxy-4-megastigmen-3-one 9-glucoside | 1.6 | 0.003 | −22.9 | Homovanillic acid sulfate | 7.8 | 0.002 | 21 | |
Aromadendrin 3,7-diglucoside | 1.3 | 0.02 | 6.9 | Aromadendrin 3,7-diglucoside | 2 | 0.002 | 13.9 | |
Hydroxybutyrylcarnitine | 1 | 0.003 | −6.2 | Pyrogallol-2-O-glucuronide | 1.5 | 0.006 | −3.5 | |
Homovanillic acid sulfate | 8.3 | 0.02 | 4.1 | Phloretin 2′-O-glucuronide | 1.3 | 0.002 | 3.4 | |
Taurocholic acid | 0.5 | 0.003 | 4 | Prenyl glucoside | 2 | 0.002 | −3.1 | |
N-Heptanoylglycine | 4.7 | 0.011 | −3.9 | Caffeic acid 3-sulfate | 4.7 | 0.002 | 2.3 | |
Cicerin 7-(6-malonylglucoside) | 3.5 | 0.003 | 3.7 | 4-Hydroxyphenylpyruvic acid | 1.7 | 0.003 | 2.3 | |
Porric acid B | 3.3 | 0.003 | −3.7 | Tyrosyl-Valine | 1.4 | 0.006 | 2.3 | |
Phloretin 2′-O-glucuronide | 1.2 | 0.003 | 3.6 | Dibutyl malate | 1.7 | 0.002 | 2.1 | |
Phenylacetylglycine | 0.4 | 0.003 | −3.4 | Ergothioneine | 0.3 | 0.002 | 2.1 | |
20-oxo-leukotriene B4 | 2.1 | 0.003 | 3.3 | Taurocholic acid | 0.3 | 0.002 | 2 | |
Tyrosyl-Valine | 1.8 | 0.003 | 3.3 | Indole-3-carboxilic acid-O-sulphate | 4.9 | 0.002 | 1.9 | |
LysoPC(16:1(9Z)) | 0.5 | 0.003 | 2.9 | 7-Methoxy-5-prenyloxycoumarin | 2.4 | 0.002 | 1.9 | |
3b,8b-Dihydroxy-6b-angeloyloxy-7(11)-eremophilen-12,8-olide | 1.8 | 0.003 | 2.7 | 5-Acetyl-2,4-dimethyloxazole | 2.2 | 0.002 | 1.7 | |
Indole-3-carboxilic acid-O-sulphate | 1.7 | 0.003 | 2.7 | 3,5-Dihydroxy-3′,4′-dimethoxy-6,7-methylenedioxyflavone 3-glucuronide | 5.6 | 0.004 | −3.7 | |
Caffeic acid 4-sulfate | 2.5 | 0.003 | −2.7 | 3-Formyl-6-hydroxyindole | 1.2 | 0.017 | 3.6 | |
Phenylpropionylglycine | 4.8 | 0.011 | −2.4 | Formononetin 7-O-glucuronide | 2.3 | 0.004 | 1.7 | |
Ergothioneine | 0.3 | 0.003 | 2.1 | Indoxyl glucuronide* | 3.2 | 0.004 | −1.7 | |
Hippuric acid | 1.4 | 0.034 | −2 | |||||
βKO Only | 4-Methoxyphenylacetic acid | 2.3 | 1.4 | |||||
3-Methoxy-4-hydroxyphenylethyleneglycol sulfate | 14.2 | 1.3 | ||||||
Riboflavin | 2.5 | −1.3 | ||||||