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Table 7 Summary of differentiating urinary metabolites in WT and meprin βKO mice at 4- and 8-weeks post STZ with a 2 ≤ FC and/or 2 ≤ VIP. A variable importance in projection (VIP) score 2 ≤ are considered to have strong predictive value. Differentiating Urinary metabolites that are independent of meprin β expression (levels change in both WT and meprin βKO mice)

From: Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy

4 Weeks post STZ

8 weeks post-STZ

 

WT

βKO

 

WT

βKO

VIP

P-value*

FC**

VIP

P-value*

FC**

VIP

P-value*

FC**

VIP

P-value*

FC**

a-L-threo-4-Hex-4-enopyranuronosyl-D-galacturonic acid

2.8

0.003

− 172.7

3.9

 

−20.8

a-L-threo-4-Hex-4-enopyranuronosyl-D-galacturonic acid

2.4

0.003

−22.5

3.3

0.052

−4.3

S-(Formylmethyl)glutathione

1.4

0.003

−31

2.7

 

−5.6

9,13-Dihydroxy-4-megastigmen-3-one 9-glucoside

1.7

0.002

−19.1

1.5

0.004

−3.5

1-Pyrroline-4-hydroxy-2-carboxylate

2.5

0.003

−13.2

2.6

 

−3.6

S-(Formylmethyl)glutathione

1.2

0.002

−8.4

2.6

0.126

−2.3

Avenic acid B

1.4

0.003

−7.3

2.5

 

−4.8

1-Pyrroline-4-hydroxy-2-carboxylate

2.6

0.002

−7.7

2.1

0.017

−2.8

Glycerophosphocholine

3.9

0.003

−6.9

2.6

 

−3

Hydroxybutyrylcarnitine

1.1

0.002

−6.5

1.7

0.004

−5.4

Nicotinic acid

3.3

0.003

−5.9

3.8

 

−3.1

Cicerin 7-(6-malonylglucoside)

4

0.006

5.8

1.4

0.004

1.8

Indole-3-carboxylic acid

2.4

0.003

−4.8

2.3

 

−2.2

Avenic acid B

1.5

0.002

−5.8

1.5

0.009

−1.7

Pyrogallol-2-O-glucuronide

1.7

0.003

−4.8

2.2

 

−2.6

Glycerophosphocholine

4

0.002

−4.8

4.1

0.017

−2.2

N-a-Acetyl-L-arginine

2.9

0.003

−3.3

2.4

 

−1.6

Indole-3-carboxylic acid

2.7

0.002

−4.8

2.5

0.004

−3

N-Carboxyethyl-g-aminobutyric acid

1.5

0.003

−3.3

2.2

 

−2.8

N-Carboxyethyl-g-aminobutyric acid

2

0.002

−4.8

1.8

0.03

−1.8

Galactonic acid

4.3

0.003

−3.1

5.2

 

−2.5

Nicotinic acid

3.3

0.002

−3.6

3.9

0.004

−2.4

4-Hydroxyphenylpyruvic acid

2.5

0.003

2.6

2.2

 

4.8

Porric acid B

3.5

0.002

−3.4

3.3

0.052

−1.6

Symmetric dimethylarginine

3.5

0.003

−2.6

4.3

 

−2.3

1,3,5-Trimethoxybenzene

2.1

0.002

−3.1

1.5

0.009

−1.6

7-Methoxy-5-prenyloxycoumarin

2.6

0.003

2.5

2.3

 

1.6

Phenylacetylglycine

0.4

0.002

−3

0.4

0.004

−2.6

Indoxylglucuronide

1.8

0.034

−2.5

3.5

 

−2

N-Acetylleucine

6.4

0.006

2.7

5.2

0.329

1.3

Caffeic acid 3-sulfate

6.6

0.003

2.4

5.8

 

4.2

20-oxo-leukotriene B4

1.7

0.003

2.6

1.8

0.009

2.3

Genistein 5-O-glucuronide

3.2

0.003

2.3

2.9

 

1.2

N-Heptanoylglycine

4.4

0.006

−2.6

6.7

0.017

−3.9

N-Acetylleucine

7.5

0.02

2.2

7

 

2

Indole-3-carboxilic acid-O-sulphate

1.8

0.002

2.4

0.6

0.004

3.3

Betaine

4.1

0.006

2

3.2

 

1.5

L-Carnitine

4.6

0.002

−2.4

6.2

0.03

−1.7

Indole-3-carboxilic acid-O-sulphate

3.9

0.02

1.6

2.4

 

1.8

D-1,5-Anhydrofructose

0.5

0.003

−2.2

1.1

0.004

−2.3

5-Acetyl-2,4-dimethyloxazole

2.3

0.003

1.7

2.6

 

1.7

Galactonic acid

3.8

0.003

−2.1

4.2

0.177

−2.1

Lotaustralin

2.5

0.003

1.8

2.4

 

1.6

Genistein 5-O-glucuronide

2.6

0.03

1.8

3.3

0.004

1.6

Fenoprofen glucuronide

6.7

0.003

1.6

10

 

1.5

Equol 7-O-glucuronide

3.5

0.003

1.7

4.6

0.004

1.5

Equol 7-O-glucuronide

3.2

0.003

1.6

4.1

 

1.5

Isovalerylalanine

4.7

0.03

−1.5

7.6

0.052

−3.7

       

Indolelactic acid

4.6

0.065

−1.5

5.8

0.082

−1.5

  1. p-value* : p-value for Exact Wilcoxon Rank Sum Test
  2. FC**: A positive or negative fold change indicates median of STZ > median of NaC