Group 1: changed levels in plasma associate with meprin expression or deficiency
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Taurocholic acid
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Increases in WT
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Bile acids/lipid metabolism
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LysoPC(16:1(9Z))
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Decreases in WT
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Lipid metabolism
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Indoxyl sulfate
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Increases in WT
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oxidative stress
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Group 2: 8 changes in urine associate with meprin β expression or deficiency
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Taurocholic acida
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Increase in WT
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Bile acids (lipid metabolism)
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Ergothioneinea
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Increase in WT
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Gut/dietary source (histidine metabolism)
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Tyrosyl-Valinea
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Increase in WT
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Protein degradation (aromatic amino acid metabolism)
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Prenyl glucoside
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Decrease in WT
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Gut/dietary (fatty acyl glucoside)
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Homovanillic acid sulfate
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increase in WT
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Catecholamine metabolism
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Cortisol
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Increase in WT
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Steroid hormone synthesis/stress response
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Aromadendrin 3,7-diglucoside
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Increase in WT
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Gut/dietary (flavonoid)
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Phloretin 2′-O-glucuronidea
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Increase in WT
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Gut/dietary (flavonoid)
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3,5-Dihydroxy-3′,4′-dimethoxy-6,7- methylenedioxyflavone 3-glucuronide
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Decrease in βKO
|
Gut/dietary
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Pantothenic acid
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Decrease in βKO
|
Gut/dietary
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Indoxyl glucuronide
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Decrease in βKO
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Indole metabolism/gut microbiota
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Group 3: changed levels in plasma associate with STZ-induced type 1 diabetes but independent of meprin β expression
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Hippuric acida
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Increase at 4 and 8 weeks
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Amino acid metabolism (phenylalanine polyphenol metabolism; uremia)
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Indole-3-carboxilic acid-O-sulphatea
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Increase
|
Indole metabolism
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Fenoprofen glucuronidea
|
Increase
|
NSAID metabolite
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Group 4: Changed levels in urine associate with STZ-induced type 1 diabetes but independent of meprin β expression
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Glycerophosphocholine
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Decrease
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Lipid metabolism (choline metabolism; glycerophosphocholine)
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Nicotinic acid
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Decrease
|
Co-factor and vitamin (nicotinate and nicotinamide metabolism)
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1-Pyrroline-4-hydroxy-2-carboxylate
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Decrease
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Amino acid metabolism (arginine and proline metabolism)
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Indole-3-carboxylic acid
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Decrease
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Gut/Dietary (indole metabolism)
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a-L-threo-4-Hex-4-enopyranuronosyl-D-galacturonic acid
|
Decrease
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Carbohydrate metabolism (glucuronic acid derivative)
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