Table 1 Baseline characteristics of participants. eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; OGTT, oral glucose tolerance test, PCR, protein creatinine ratio; TG, triglycerides. NS is not significant when P-value is > 0.05.
Group 1 (Standard care) | Group 2 (Intervention) | P-value | |
|---|---|---|---|
Number of patients | 9 | 10 | |
Females | 2 (22%) | 6 (60%) | 0.04 |
Age (years) | 48.5 (SD 11.6) | 43.4 (SD 9.3) | NS |
Fasting glucose (mmol/L) | 5.3 (SD 0.7) | 5.4 (SD 0.4) | NS |
2 h glucose at OGTT (mmol/L) | 9.3 (SD 0.84) | 9.8 (SD 0.7) | NS |
Body mass index | 28.9 (SD 5.6) | 26.9 (SD 4.8) | NS |
Hba1c (mmol/mol) | 35.8 (SD 5.5) | 33.8 (SD 3.7) | NS |
Creatinine (micromol/L) | 136.3 (SD 36.6) | 111.4 (SD 37.9) | NS |
eGFR in MDRD (ml/min) | 55.1 (SD 16.5) | 61.4 (SD 20) | NS |
GI quality of life | 3.1 (SD 3.4) | 1.4 (SD 2.5) | NS |
Serum cholesterol (mmol/L) | 6.2 (SD 1.1) | 6.2 (SD 1.2) | NS |
Serum TG (mmol/L) | 2 (SD 0.9) | 2.6 (SD 1) | NS |
Systolic BP (mm Hg) | 142.3 (SD 16.3) | 125.3 (SD 11.4) | NS |
Diastolic BP (mm Hg) | 85.3 (SD 8.8) | 78.9 (SD 7.7) | NS |
Duration between transplant and enrolment | 31.8 (SD 6.8) | 42.3 (SD 19.8) | 0.001 |
Urine PCR (mg/mmol) | 36 (SD 22.2) | 53.8 (SD 35.4) | NS |
Steroids dose at randomisation (mg) | 17.5 (SD 2.6) | 13.9 (SD 3.3) | 0.024 |
Number of patients on tacrolimus | 3 (33%) | 6 (60%) | NS |