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Fig. 2 | BMC Nephrology

Fig. 2

From: miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma

Fig. 2

Effect of YAP knockdown on cell growth, colony formation, migration and invasion of RCC cells. a qRT-PCR showed a marked reduction of YAP expression in 786-O and A498 cells with YAP knockdown. b MTT assay showed that knockdown of YAP in 786-O and A498 cells significantly reduced cell viability compared with the parental cells. c Colony formation assay showed that 786-O and A498 cells with YAP knockdown formed fewer colonies compared with the parental cells. d Wound-healing assay. Cells were quantified by counting three separate fields in different cells. The migratory ability of 786-O and A498 cells with YAP knockdown were remarkably decreased than those of parental cells. e Transwell assay. The invasion and migration number of cells in 786-O and A498 cells with YAP knockdown were lower than those in the parental cells. *P < 0.05, **P < 0.01, compared to cells treated with control

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BMC Nephrology

ISSN: 1471-2369

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