Fig. 4From: S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1Inhibition of ROCK1 reverses HG-induced endothelial cell dysfunctions. HEGECs were pretreated with the ROCK1 inhibitor Y27632 for 30 min and then incubated with normal glucose (NG) or high glucose (HG) for 72 h. Cell permeability (a), apoptosis (b), and migration (c) were assessed as described in Fig. 3. Results are expressed as mean ± SD of three independent experiments. *P < 0.05 versus the HG group; #P < 0.05 versus the NG groupBack to article page