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Table 1 Differences of demographic and clinical characteristics between IgAN patients and non-IgAN patients

From: High serum IgA/C3 ratio better predicts a diagnosis of IgA nephropathy among primary glomerular nephropathy patients with proteinuria ≤ 1 g/d: an observational cross-sectional study

 

Full cohort

PSM cohort

non-IgAN (N = 338)

IgAN (N = 757)

Total (N = 1095)

P

non-IgAN (N = 204)

IgAN (N = 204)

Total (N = 408)

P

Age (years)

40.56 ± 16.48

32.17 ± 10.84

34.76 ± 13.42

< 0.001

42.96 ± 16.15

30.22 ± 11.18

36.59 ± 15.27

< 0.001

Male: female ratio

199:139

342:415

541:554

< 0.001

107:97

107:97

214:194

1.000

Course (months)

3 (1–12)

7 (2–14)

6 (1–24)

< 0.001

6 (1–18)

6 (1–24)

6 (1–22.5)

0.978

Clinic-SBP (mmHg)

132.95 ± 20.01

145.08 ± 26.42

141.64 ± 25.36

< 0.001

132.84 ± 20.28

141.74 ± 22.95

137.82 ± 22.23

< 0.001

Clinic-DBP (mmHg)

83.10 ± 12.38

92.66 ± 18.96

89.95 ± 17.87

< 0.001

83.00 ± 12.69

89.78 ± 16.11

86.79 ± 15.06

< 0.001

CKD stage

   

< 0.001

   

0.016

CKD1 (N/%)

165 (48.82%)

311 (41.08%)

476 (43.47%)

 

92 (45.10%)

98 (48.04%)

190 (46.57%)

 

CKD2 (N/%)

115 (34.02%)

233 (30.78%)

348 (31.78%)

 

74 (36.27%)

50 (24.51%)

124 (30.39%)

 

CKD3–5 (N/%)

58 (17.16%)

213 (28.14%)

271 (24.75%)

 

38 (18.63%)

56 (27.45%)

94 (23.04%)

 

BMI (kg/m2)

23.64 ± 4.69

22.74 ± 3.78

23.23 ± 4.31

0.037

23.55 ± 4.96

22.47 ± 3.23

23.06 ± 4.29

0.055

Hematuria (N/%)

244 (72.19%)

592 (78.20%)

836 (76.35%)

0.031

145 (71.08%)

166 (81.37%)

311 (76.23%)

0.015

Proteinuria (g/d)

4.00 (2.17–6.90)

0.59 (0.22–1.50)

1.04 (0.34–3.46)

< 0.001

2.63 (1.21–4.06)

2.55 (0.75–4.38)

2.56 (0.96–4.21)

0.427

Proteinuria classifications

   

< 0.001

   

0.482

Proteinuria ≤1 g/d (N/%)

47 (13.91%)

495 (65.39%)

542 (49.50%)

 

47 (23.04%)

57 (27.94%)

104 (25.49%)

 

Proteinuria 1–3.5 g/d (N/%)

99 (29.29%)

190 (25.10%)

289 (26.39%)

 

87 (42.65%)

78 (38.24%)

165 (40.44%)

 

Proteinuria > 3.5 g/d (N/%)

192 (56.80%)

72 (9.51%)

264 (24.11%)

 

70 (34.31%)

69 (33.82%)

139 (34.07%)

 

Hemoglobin (g/L)

130.93 ± 20.51

126.22 ± 22.02

127.69 ± 21.66

0.001

129.28 ± 19.39

125.85 ± 23.62

127.58 ± 21.63

0.112

Albumin (g/L)

24.80 ± 8.23

38.32 ± 7.43

34.12 ± 9.91

< 0.001

27.27 ± 8.88

33.92 ± 8.89

30.57 ± 9.48

< 0.001

Globulin (g/L)

21.13 ± 4.41

26.34 ± 4.86

24.71 ± 5.30

< 0.001

21.84 ± 4.42

24.08 ± 4.31

22.97 ± 4.50

< 0.001

fasting glucose (mmol/L)

5.07 ± 1.41

4.90 ± 0.96

4.99 ± 1.23

0.086

5.14 ± 1.49

4.84 ± 1.13

5.02 ± 1.37

0.051

Cholesterol (mmol/L)

8.61 ± 3.37

5.40 ± 2.14

6.40 ± 2.98

< 0.001

7.74 ± 3.38

6.41 ± 3.17

7.08 ± 3.34

< 0.001

Triglyceride (mmol/L)

2.41 ± 1.83

1.62 ± 1.37

1.87 ± 1.57

< 0.001

2.13 ± 1.43

1.96 ± 1.48

2.05 ± 1.46

0.257

HDL-C (mmol/L)

1.49 ± 0.50

1.30 ± 0.42

1.36 ± 0.45

< 0.001

1.48 ± 0.51

1.34 ± 0.44

1.41 ± 0.48

0.002

LDL-C (mmol/L)

5.69 ± 2.58

3.18 ± 1.53

4.01 ± 2.27

< 0.001

5.01 ± 2.51

3.98 ± 2.23

4.51 ± 2.43

< 0.001

Uric acid (mmol/L)

410.59 ± 120.67

422.00 ± 130.89

416.03 ± 125.68

0.254

408.26 ± 119.47

422.17 ± 138.14

413.75 ± 127.14

0.331

Serum Cystatin C (mg/L)

1.18 ± 0.66

1.42 ± 1.12

1.30 ± 0.92

0.002

1.23 ± 0.76

1.40 ± 1.13

1.30 ± 0.94

0.159

Blood urea nitrogen (mmol/L)

5.89 (4.40–9.27)

6.51 (4.84–10.01)

6.30 (4.57–9.56)

0.054

6.35 (4.54–9.56)

6.05 (4.58–9.31)

6.16 (4.56–9.52)

0.523

Serum creatinine (μmol/L)

76.00 (61.00–97.93)

80.50 (64.00–118.05)

78.70 (62.10–109.00)

0.002

76.60 (57.43–100.90)

78.00 (58.00–127.90)

77.65 (58.00–112.68)

0.196

eGFR-MDRD (ml/min/1.73m2)

90.28 ± 35.21

81.79 ± 38.50

84.43 ± 37.70

< 0.001

88.98 ± 38.83

91.36 ± 57.27

90.17 ± 48.88

0.624

IgG (g/L)

6.52 ± 3.55

10.58 ± 3.46

9.34 ± 3.96

< 0.001

7.34 ± 3.76

8.84 ± 3.74

8.09 ± 3.82

< 0.001

IgA (g/L)

2.13 ± 0.86

2.86 ± 1.11

2.64 ± 1.09

< 0.001

2.14 ± 0.85

2.84 ± 1.09

2.49 ± 1.03

< 0.001

IgM (g/L)

1.25 ± 0.65

1.44 ± 0.71

1.38 ± 0.70

< 0.001

1.24 ± 0.65

1.42 ± 0.73

1.33 ± 0.70

0.007

C3 (g/L)

1.15 ± 0.26

1.02 ± 0.26

1.06 ± 0.27

< 0.001

1.14 ± 0.26

1.05 ± 0.30

1.10 ± 0.28

0.001

C4 (g/L)

0.30 ± 0.11

0.26 ± 0.10

0.27 ± .011

< 0.001

0.30 ± 0.11

0.28 ± 0.11

0.29 ± 0.11

0.120

IgA/C3 ratio

1.94 ± 0.92

2.98 ± 1.27

2.66 ± 1.27

< 0.001

1.96 ± 0.91

2.87 ± 1.31

2.42 ± 1.22

< 0.001

increased IgA (N/%)

10 (2.96%)

97 (12.81%)

107 (9.77%)

< 0.001

5 (2.45%)

25 (12.25%)

30 (7.35%)

< 0.001

decreased C3 (N/%)

24 (7.10%)

143 (18.89%)

167 (15.25%)

< 0.001

14 (6.86%)

25 (12.25%)

39 (9.56%)

0.064

IgA/C3 ratio > 3.53 (N/%)

17 (5.03%)

196 (25.89%)

213 (19.45%)

< 0.001

10 (4.90%)

49 (24.02%)

59 (14.46%)

< 0.001

  1. BMI body mass index, C3 complement 3, C4 complement 4, CKD chronic kidney disease, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, HDL-C high-density lipoprotein cholesterol, IgA immunoglobulin A, IgAN immunoglobulin A nephrology, IgG immunoglobulin G, IgM immunoglobulin M, LDL-C low-density lipoprotein cholesterol, PSM propensity score matched, SBP systolic blood pressure
  2. P value for analysis of comparison between IgAN patients and non-IgAN patients
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BMC Nephrology

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