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Table 5 Multivariate logistic regression analysis for IgAN (1 = non-IgAN; 2 = IgAN) in the full cohort

From: High serum IgA/C3 ratio better predicts a diagnosis of IgA nephropathy among primary glomerular nephropathy patients with proteinuria ≤ 1 g/d: an observational cross-sectional study

 

OR (95% CI)

P Value

Model 1 R2 = 0.233

 IgA/C3 ratio (per 1)

2.676 (2.268–3.158)

< 0.001

Model 2 R2 = 0.229

 Age (per 1 year)

0.952 (0.941–0.962)

< 0.001

 IgA/C3 ratio (per 1)

2.742 (2.307–3.260)

< 0.001

Model 3 R2 = 0.360

 Age (per 1 year)

0.936 (0.923–0.948)

< 0.001

 IgG (per 1 mmol/L)

1.385 (1.315–1.458)

< 0.001

 IgA/C3 ratio (per 1)

2.051 (1.702–2.471)

< 0.001

Model 4 R2 = 0.466

 Age (per 1 year)

0.932 (0.918–0.947)

< 0.001

 Albumin (per 1 g/L)

1.198 (1.171–1.226)

< 0.001

CKD stage

 CKD2 (versus CKD1)

2.278 (1.407–3.687)

0.001

 CKD3–5 (versus CKD1)

4.782 (2.766–8.269)

< 0.001

 IgA/C3 ratio (per 1)

2.159 (1.759–2.650)

< 0.001

  1. Model 1: IgA/C3 ratio, univariate
  2. Model 2: IgA/C3 ratio, age and gender (male = 1; female = 2) adjusted
  3. Model 3: IgA/C3 ratio, age, gender (male = 1; female = 2), IgG, IgA, IgM, C3, C4 adjusted
  4. Model 4: multivariable adjusted
  5. Variables of univariate regression analysis include age, gender (male = 1, female = 2), course, clinic-SBP, clinic-DBP, BMI, hematuria, Lg (proteinuria), proteinuria stage, hemoglobin, albumin, uric acid, serum cystatin, blood urea nitrogen, serum creatinine, eGFR-MDRD, CKD stage, IgG, IgA, IgM, C3, C4 and IgA/C3 ratio
  6. All variables with significant associations in univariate regression analysis were included in Model 4 multivariate regression analysis
  7. BMI body mass index, C3 complement 3, C4 complement 4, CI confidence interval, CKD chronic kidney disease, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, HDL-C high-density lipoprotein cholesterol, IgA immunoglobulin A, IgAN immunoglobulin A nephrology, IgG immunoglobulin G, IgM immunoglobulin M, LDL-C low-density lipoprotein cholesterol, OR odds ratio, PSM propensity score matched, SBP systolic blood pressure