Table 3 Predictors of changes in estimated glomerular filtration rate
eGFRa (ml/min/1.73m2/year) | CI95% | p-value | eGFRa (ml/min/1.73m2/year) | CI95% | p-value | ||
|---|---|---|---|---|---|---|---|
During first year | After first year | ||||||
Baseline eGFR ≥ 90 ml/min/1.73m2, N = 2528 | |||||||
Baseline age, years | Ref (< 40) | – | – | – | – | – | – |
40–49 | 1.7 | [− 0.1;3.5] | 0.060 | 0.2 | [− 0.2;0.6] | 0.242 | |
≥ 50 | −0.7 | [− 3.2;1.8] | 0.590 | 0.6 | [−0.2;1.0] | 0.197 | |
Baseline BMI ≥ 25 Kg/m2 | 0.3 | [− 1.9;2.5] | 0.787 | 0.5 | [0.0;1.0] | 0.050 | |
Baseline High Blood Pressure | 0.3 | [−2.5;3.1] | 0.829 | 0.1 | [−0.5;0.7] | 0.738 | |
WHO stage ≥3 | 0.4 | [−1.1;2.0] | 0.591 | −0.2 | [−0.5;0.1] | 0.236 | |
Baseline CD4 count < 100 cells/μl | −2.7 | [−4.4;-1.0] | 0.002 | − 0.5 | [− 0.8;-0.1] | 0.015 | |
cART exposure | Ref(AZT without PI) | – | – | – | – | – | – |
AZT + PI | −4.7 | [−7.7;-1.6] | 0.002 | 0.1 | [−0.5;0.6] | 0.856 | |
TDF without PI | −3.2 | [−5.0;-1.4] | < 0.001 | −0.2 | [− 0.6;0.2] | 0.326 | |
TDF + PI | −13.1 | [− 17.4;-8.7] | < 0.001 | − 0.1 | [−0.7;0.6] | 0.838 | |
d4T without PI | −5.0 | [−7.6;-2.4] | < 0.001 | 2.7 | [1.0;4.4] | 0.002 | |
d4T + PI | −8.5 | [− 14.6;-2.4] | 0.006 | 3.4 | [−1.4;8.2] | 0.171 | |
ABC/ddI | 0.2 | [−12.8;13.1] | 0.981 | 0.1 | [−1.0;1.2] | 0.884 | |
Baseline eGFR between 60 and 89 ml/min/1.73m2, N = 517 | |||||||
Baseline age, years | Ref (< 40) | – | – | – | – | – | – |
40–49 | −8.3 | [−11.7;-5.0] | < 0.001 | 0.9 | [0.1;1.6] | 0.028 | |
≥ 50 | −6.2 | [−10.7;-1.8] | 0.006 | 0.7 | [−0.4;1.9] | 0.193 | |
Baseline BMI ≥ 25 Kg/m2 | −2.2 | [−6.1;1.7] | 0.273 | 0.8 | [−0.1;1.7] | 0.076 | |
Baseline High Blood Pressure | −2.7 | [−7.4;2.0] | 0.258 | 0.5 | [−0.6;1.6] | 0.362 | |
WHO stage ≥3 | 2.5 | [− 0.7;5.7] | 0.121 | −0.2 | [−0.9;0.6] | 0.652 | |
Baseline CD4 count < 100 cells/μl | 1.1 | [−2.5;4.6] | 0.549 | −1.1 | [−2.0;-0.3] | 0.009 | |
cART exposure | Ref(AZT without PI) | – | – | – | – | – | – |
AZT + PI | 0.2 | [−5.4;5.8] | 0.947 | − 0.7 | [−1.9;0.5] | 0.239 | |
TDF without PI | 1.0 | [−2.7;4.7] | 0.590 | −0.2 | [−1.0;0.6] | 0.631 | |
TDF + PI | −7.2 | [−15.8;1.6] | 0.111 | −1.1 | [− 2.6;0.5] | 0.167 | |
d4T without PI | 6.3 | [0.5;12.1] | 0.034 | −1.3 | [−6.6;3.6] | 0.601 | |
d4T + PI | −0.3 | [−16.7;16.1] | 0.974 | −20.7 | [− 31.8;-9.5] | < 0.001 | |
ABC/ddI | −6.6 | [−19.5;6.2] | 0.313 | 2.4 | [0.4;4.5] | 0.018 | |
Baseline eGFR < 60 ml/min/1.73m2, N = 93 | |||||||
Baseline age, years | Ref (< 40) | – | – | – | – | – | – |
40–49 | 5.4 | [−7.2;18.0] | 0.398 | 2.5 | [− 3.7;8.6] | 0.435 | |
≥ 50 | −5.6 | [−22.1;10.9] | 0.506 | −2.4 | [−10.3;5.6] | 0.564 | |
Baseline BMI ≥ 25 Kg/m2 | −14.8 | [−41.2;11.6] | 0.272 | 3.3 | [−8.5;15.1] | 0.581 | |
Baseline High Blood Pressure | −28.4 | [−46.9;-9.9] | 0.003 | −0.7 | [−9.4;8.1] | 0.879 | |
WHO stage ≥3 | 6.4 | [−6.7;19.5] | 0.336 | 3.6 | [−2.2;9.5] | 0.223 | |
Baseline CD4 count < 100 cells/μl | 7.9 | [−3.6;19.3] | 0.179 | 4.8 | [−0.8;10.4] | 0.095 | |
cART exposureb | Ref(AZT without PI) | – | – | – | – | – | – |
AZT + PI | 9.3 | [−20.3;38.9] | 0.537 | 10.0 | [− 0.3;20.3] | 0.058 | |
TDF without PI | −18.9 | [−33.9;-3.8] | 0.014 | 1.4 | [−2.8;5.6] | 0.520 | |
d4T without PI | −22.2 | [−41.5;-2.9] | 0.024 | −26.1 | [−51.6;-0.5] | 0.045 | |
ABC/ddI | −19.6 | [−36.2;-3.0] | 0.020 | 2.5 | [−3.6;8.5] | 0.425 | |