From: Randomized, open-label, comparative phase IV study on the bioavailability of Ciclosporin Pro (Teva) versus Sandimmun® Optoral (Novartis) under fasting versus fed conditions in patients with stable renal transplants
eGFR (MDRD) [ml/min/1.73 m2]
A: fasting→fed
B: fed→fasting
Total
Baseline
38.8 ± 8.8
38.7 ± 11.0
38.7 ± 9.7
Day 29 (PK2)
38.7 ± 10.9
43.5 ± 9.1
41.2 ± 10.0
Day 58 (PK4)
39.8 ± 8.7
40.4 ± 11.4
40.1 ± 10.1