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Table 3 AUCSS, τ [h*ng/ml], CSS, max [ng/ml], and CSS, min [ng/ml] for each treatment and nutrition condition (PP; n = 21)

From: Randomized, open-label, comparative phase IV study on the bioavailability of Ciclosporin Pro (Teva) versus Sandimmun® Optoral (Novartis) under fasting versus fed conditions in patients with stable renal transplants

  Ciclosporin Pro Sandimmun Optoral
fasting high-fat fasting high-fat
Geom. mean 95% CI CV % Geom. mean 95% CI CV % Geom. mean 95% CI CV % Geom. mean 95% CI CV %
AUC 3006.5 [2652.7;3407.5] 28.0 2652.7 [2334.5;3014.2] 28.6 3228.6 [2857.8;3647.6] 27.3 2711.2 [2357.7;3117.7] 31.4
Cmax 844.6 [702.4;1015.7] 42.2 570.9 [463.6;703.2] 48.3 940.6 [802.7;1102.3] 35.9 560.2 [454.3;690.8] 48.6
Cmin 97.9 [87.1;110.1] 26.2 91.4 [81.1;103.0] 26.7 100.0 [88.8;112.5] 26.4 97.7 [86.9;109.9] 26.2