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Table 1 Demographic, clinical and serological characteristics of patients with pSS-related TIN and GMN

From: Clinical significance of C4d deposition in renal tissues from patients with primary Sjögren’s syndrome—a preliminary study

Items

Total (n = 39)

TIN (n = 21)

GMN (n = 18)

P

Age at KB (years, M ± SD)

42 ± 14.1

36 ± 12.5

48 ± 13.5

0.008

Male:female ratio

9/30

3/18

6/12

NS

PSS duration (years, IQR)

5.0 [2.0, 16.0]

3.0 [1.75, 7.50]

11.5 [2.0, 20.0]

0.025

IS therapy (%)

15/39 (38.5)

8/21

7/18

NS

ANA (+) (%)

37/39 (94.9)

21/21

16/18

NS

 ANA 1:1280 (+) (%)

8/39 (20.5)

5/21

3/18

NS

 ANA 1:640 (+) (%)

16/39 (41.0)

11/21

5/18

NS

Anti-SSA (+) (%)

34/39 (87.2)

18/21

16/18

NS

Anti-SSB (+) (%)

13/39 (33.3)

9/21

4/18

NS

Serum IgG elevation (%)

25/38 (65.8)

17/20

8/18

0.016

Serum IgA elevation (%)

14/38 (36.8)

6/20

8/18

NS

Serum IgM elevation (%)

4/38 (10.5)

3/20

1/18

NS

HypocomplementemiaLow CH50

3/38 (7.9)

0/20

3/18

NS

 Low C3

6/38 (15.8)

1/20

5/18

NS

 Low C4

6/35 (17.1)

2/17

4/18

NS

RTA(%)

22/39 (56.4)

20/21

2/18

< 0.001

Urinary calcification/stone (%)

12/39 (30.8)

10/21

2/18

0.018

Microhaematuria (%)

18/39 (46.2)

5/21

13/18

0.004

Proteinuria (%)

 Mild (< 1.5 g/day)

25/39 (64.1)

17/21 (81.0)

8/18 (44.4)

 

 Moderate (1.5–3.5 g/day)

7/39 (17.9)

4/21 (19.0)

3/18 (16.7)

0.006

 Nephrotic range (> 3.5 g/day)

7/39 (17.9)

0/21 (0)

7/18 (38.9)

 

24-h urine collection (g/day, M ± SD)

2.2 ± 3.7

0.8 ± 0.6

3.9 ± 4.9

0.033

Scr (μmol/L, M ± SD)

103.9 ± 40.99

113.2 ± 42.33

93.0 ± 37.60

NS

eGFR (mL/min.1.73 m2, M ± SD)

70.2 ± 27.23

64.0 ± 28.17

77.5 ± 24.90

NS

  1. NS not significant, TIN tubular interstitial nephritis, GMN glomerulonephritis, KB kidney biopsy, IS immunosuppression, ANA anti-nuclear antibodies, RTA renal tubular acidosis, Scr serum creatinine, eGFR estimated glomerular filtration rate (calculated with the CKD-EPI creatinine equation), M ± SD mean ± standard deviation, IQR interquartile range