Fig. 1

Effect of saline and furosemide on urinary excretion rate of neutrophil gelatinase-associated lipocalin (NGAL) (a) and kidney injury molecule − 1 (KIM-1) (b) in a randomized cross-over study of 24 healthy subjects. Urine was collected every 30 min in the 90 min baseline period, once after 60 min of 3% saline infusion, and every 30 min 90 min after hypertonic saline infusion and once 150 min after cessation of hypertonic saline infusion. Data from three baseline periods are pooled and shown as one period. Data are shown as medians with 25 and 75 percentiles in brackets. P-value represents probability of difference in response to hypertonic saline (response from baseline to hypertonic saline) between treatments Statistics are performed with a general linear model (GLM), and data were logarithmic transformed before GLM was performed. Difference in response from baseline between treatments are marked with * if p <  0.05 with a student’s t-test