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Table 1 24-h urine collection prior to two examinations in a randomized, cross-over study of 24 healthy subjects

From: Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects – a randomized controlled trial

  Placebo Furosemide P-value
Urine output (mL/minute) 1.84 ± 0.36 1.73 ± 0.39 0.242
CH2O (mL/minute) −0.23 ± 0,61 −0.15 ± 0.38 0.436
U-creatinine (mmol/24 h) 15.5 ± 4.1 15.2 ± 4.0 0.917
Creatinine clearance (mmol/mL pr. m2) 134 ± 24 130 ± 19 0.753
U-Na (mmol/24 h) 124 ± 37 100 ± 28 0.017
FENa (%) 0.62 ± 0.19 0.57 ± 0.9 0.016
U-Cl (mmol/24 h) 128 ± 31 108 ± 27 0.052
U-K (mmol/24 h) 62 ± 14 62 ± 23 0.601
FEK (%) 10.8 ± 2.3 11.1 ± 4.4 0.438
UAER (mg/24 h) 7 (4;10) 7 (5;9) 0.440
U-AQP-2/min (ng/minute) 0.81 ± 0.31 0.77 ± 0.20 0.562
U-AQP-2/creatinine (ng/mmol) 75 ± 15 76 ± 22 0.826
U-ENaCγ / min (ng/minute) 0.79 ± 0.30 0.71 ± 0.25 0.430
U-ENaCγ /creatinine (ng/mmol) 77 ± 30 70 ± 24 0.327
U-NGAL / min (ng/min) 16 (7;43) 15 (7;27) 0.063
U-NGAL /creatinine (ng/mmol) 1401 (649;4777) 1409 (524;3433) 0.109
U-KIM-1 / min (ng/min) 0.41 ± 0.21 0.41 ± 0.20 0.580
U-KIM-1 /creatinine (ng/mmol) 39 ± 23 40 ± 19 0.831
  1. Urine output, CH2O free water clearance, U-Na urine excretion of sodium, and U-K potassium, FENa fractional excretion of sodium, and FEK potassium, creatinine clearance, UAER urinary excretions rates of albumin, u-AQP-2/min aquaporin-2, u-ENaCγ/min γ-fraction of the epithelial sodium channel, u-NGAL/min neutrophil gelatinase-associated lipocalin and u-KIM-1/min kidney injury molecule-1 and in relation to creatinine (u-AQP-2/creatinine, u-ENaCγ/creatinine, u-NGAL/creatinine, u-KIM-1/creatinine. Urine were collected from 07.00 am on the day before the day of examination day to 07.00 am on the day of examination. Data are shown as means ± SD in brackets or medians with 25 and 75 percentiles in brackets. Statistics are performed with paired t-test or Wilcoxon signed rank test