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Table 1 24-h urine collection prior to two examinations in a randomized, cross-over study of 24 healthy subjects

From: Effect of 3% saline and furosemide on biomarkers of kidney injury and renal tubular function and GFR in healthy subjects – a randomized controlled trial

 

Placebo

Furosemide

P-value

Urine output (mL/minute)

1.84 ± 0.36

1.73 ± 0.39

0.242

CH2O (mL/minute)

−0.23 ± 0,61

−0.15 ± 0.38

0.436

U-creatinine (mmol/24 h)

15.5 ± 4.1

15.2 ± 4.0

0.917

Creatinine clearance (mmol/mL pr. m2)

134 ± 24

130 ± 19

0.753

U-Na (mmol/24 h)

124 ± 37

100 ± 28

0.017

FENa (%)

0.62 ± 0.19

0.57 ± 0.9

0.016

U-Cl (mmol/24 h)

128 ± 31

108 ± 27

0.052

U-K (mmol/24 h)

62 ± 14

62 ± 23

0.601

FEK (%)

10.8 ± 2.3

11.1 ± 4.4

0.438

UAER (mg/24 h)

7 (4;10)

7 (5;9)

0.440

U-AQP-2/min (ng/minute)

0.81 ± 0.31

0.77 ± 0.20

0.562

U-AQP-2/creatinine (ng/mmol)

75 ± 15

76 ± 22

0.826

U-ENaCγ / min (ng/minute)

0.79 ± 0.30

0.71 ± 0.25

0.430

U-ENaCγ /creatinine (ng/mmol)

77 ± 30

70 ± 24

0.327

U-NGAL / min (ng/min)

16 (7;43)

15 (7;27)

0.063

U-NGAL /creatinine (ng/mmol)

1401 (649;4777)

1409 (524;3433)

0.109

U-KIM-1 / min (ng/min)

0.41 ± 0.21

0.41 ± 0.20

0.580

U-KIM-1 /creatinine (ng/mmol)

39 ± 23

40 ± 19

0.831

  1. Urine output, CH2O free water clearance, U-Na urine excretion of sodium, and U-K potassium, FENa fractional excretion of sodium, and FEK potassium, creatinine clearance, UAER urinary excretions rates of albumin, u-AQP-2/min aquaporin-2, u-ENaCγ/min γ-fraction of the epithelial sodium channel, u-NGAL/min neutrophil gelatinase-associated lipocalin and u-KIM-1/min kidney injury molecule-1 and in relation to creatinine (u-AQP-2/creatinine, u-ENaCγ/creatinine, u-NGAL/creatinine, u-KIM-1/creatinine. Urine were collected from 07.00 am on the day before the day of examination day to 07.00 am on the day of examination. Data are shown as means ± SD in brackets or medians with 25 and 75 percentiles in brackets. Statistics are performed with paired t-test or Wilcoxon signed rank test