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Table 6 Adjusted hazard ratios of immunosuppressants for clinical pregnancy and duration

From: Effect of deflazacort on pregnancy outcome in kidney transplant patients: should we change the immunosuppressant before conception?

Immunosuppressant Unadjusted HR (95% CI) P value Adjusted HR (95% CI) P value
CyA 0.89 (0.37–2.14) 0.8 0.33 (0.1–1.09) 0.07
TAC 1.16 (0.49–2.79) 0.73 2.99 (0.92–9.72) 0.07
DFZ 0.23 (0.05–0.99) 0.05 0.17 (0.03–0.86) 0.03
Pred 1.28 (0.53–3.11) 0.59 1.06 (0.42–2.72) 0.9
Aza 0.31 (0.07–1.34) 0.12 0.36 (0.08–1.77) 0.21
MMF 0.57 (0.19–1.72) 0.32 0.61 (0.2–1.83) 0.38
Cumulative dose of DFZ (mg) 1.0 0.11 1.0 0.14
Total duration of DFZ use (months) 0.98 (0.95–1.0) 0.06 0.97 (0.95–1.0) 0.04
  1. The P-values were obtained using univariate and multivariate cox regression analyses. The analysis was adjusted for age, eGFR, graft rejection after transplantation, diabetes mellitus, and use of assisted reproductive techniques. The cox regression multivariate analysis was performed for each immunosuppressant, respectively
  2. Note: CyA cyclosporine, TAC tacrolimus, DFZ deflazacort, Pred predinosolone, Aza azathioprine, MMF mycophenolate mofetil, HR hazard ratio, CI confidence interval