| Baseline | Time-dependent | ||||||
---|---|---|---|---|---|---|---|---|
Crude | Adjusteda | Crude | Adjusted a | |||||
Variable | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI |
Age (yrs) | ||||||||
 < 45 | 1.20 | (0.74, 1.92) | 1.36 | (0.81, 2.30) |  |  |  |  |
 45–54 | 0.78 | (0.43, 1.39) | 0.83 | (0.46, 1.49) |  |  |  |  |
 55–64 | 1 | (ref) | 1 | (ref) |  |  |  |  |
 65–74 | 0.97 | (0.65, 1.47) | 0.85 | (0.52, 1.40) |  |  |  |  |
 75+ | 1.48 | (0.96, 2.26) | 1.36 | (0.83, 2.22) |  |  |  |  |
Vintage (yrs) | ||||||||
 < 1.0 | 0.78 | (0.43, 1.42) | 0.79 | (0.44, 1.42) |  |  |  |  |
 1.0–2.9 | 1 | (ref) | 1 | (ref) |  |  |  |  |
 3.0–4.9 | 1.16 | (0.78, 1.71) | 1.09 | (0.74, 1.63) |  |  |  |  |
 5.0+ | 0.92 | (0.64, 1.33) | 0.87 | (0.59, 1.28) |  |  |  |  |
BMI (kg/m2) | ||||||||
 < 18.5 | 1.49 | (0.75, 2.96) | 1.31 | (0.58, 2.97) |  |  |  |  |
 18.5–24.9 | 1.44 | (1.01, 2.07) | 1.56 | (1.05, 2.30) |  |  |  |  |
 25.0–29.9 | 1 | (ref) | 1 | (ref) |  |  |  |  |
 30.0+ | 1.17 | (0.74, 1.85) | 1.30 | (0.80, 2.12) |  |  |  |  |
Male sex | 0.98 | (0.73, 1.32) | 0.94 | (0.67, 1.30) | Â | Â | Â | Â |
Coronary artery disease | 1.48 | (1.08, 2.03) | 1.26 | (0.90, 1.74) | Â | Â | Â | Â |
Cancer | 1.40 | (0.95, 2.04) | 1.31 | (0.91, 1.89) | Â | Â | Â | Â |
Other cardiovascular disease | 1.20 | (0.80, 1.79) | 1.06 | (0.67, 1.68) | Â | Â | Â | Â |
Cerebrovascular disease | 1.53 | (1.03, 2.27) | 1.39 | (0.93, 2.06) | Â | Â | Â | Â |
Congestive heart failure | 1.51 | (1.02, 2.25) | 1.21 | (0.79, 1.85) | Â | Â | Â | Â |
Diabetes | 0.99 | (0.71, 1.38) | 0.87 | (0.57, 1.32) | Â | Â | Â | Â |
GI bleeding | 0.94 | (0.47, 1.86) | 0.76 | (0.33, 1.73) | Â | Â | Â | Â |
Hypertension | 0.88 | (0.59, 1.30) | 0.77 | (0.48, 1.23) | Â | Â | Â | Â |
Lung disease | 1.30 | (0.83, 2.03) | 1.15 | (0.73, 1.80) | Â | Â | Â | Â |
Psychiatric disorder | 1.91 | (1.29, 2.81) | 1.75 | (1.15, 2.66) | Â | Â | Â | Â |
Peripheral vascular disease | 1.40 | (1.00, 1.95) | 1.24 | (0.88, 1.74) | Â | Â | Â | Â |
Hospitalization in prior 3 months | 1.26 | (0.85, 1.87) | 1.21 | (0.79, 1.84) | 1.58 | (1.13, 2.20) | 1.40 | (1.01, 1.92) |
Serum phosphorus (mg/dl) | ||||||||
 < 3.50 | 1.31 | (0.78, 2.20) | 1.39 | (0.78, 2.49) | 1.61 | (1.11, 2.34) | 1.58 | (1.09, 2.30) |
 3.50–5.49 | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 5.50–5.99 | 1.50 | (1.02, 2.19) | 1.43 | (0.97, 2.11) | 1.43 | (0.87, 2.35) | 1.36 | (0.83, 2.21) |
 6.00+ | 0.97 | (0.70, 1.35) | 1.03 | (0.73, 1.47) | 1.05 | (0.70, 1.58) | 1.04 | (0.69, 1.57) |
Serum PTH (pg/ml) | ||||||||
 < 150 | 2.90 | (1.52, 5.12) | 2.26 | (1.24, 4.12) | 2.24 | (1.39, 3.59) | 2.57 | (1.52, 4.33) |
 150–299 | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 300–599 | 1.51 | (0.90, 2.55) | 1.47 | (0.86, 2.52) | 0.77 | (0.48, 1.25) | 0.84 | (0.52, 1.38) |
 600+ | 1.60 | (0.92, 2.81) | 1.50 | (0.85, 2.64) | 0.93 | (0.58, 1.50) | 0.96 | (0.58, 1.57) |
Serum calcium (mg/dl) | ||||||||
 < 7.50 | 1.51 | (0.67, 3.39) | 1.43 | (0.56, 3.68) | 1.97 | (0.89, 4.38) | 1.83 | (0.83, 4.04) |
 7.50–8.39 | 1.54 | (1.03, 2.31) | 1.56 | (0.99, 2.45) | 1.68 | (1.11, 2.54) | 1.65 | (1.04, 2.60) |
 8.40–10.19 | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 10.20+ | 0.91 | (0.55, 1.50) | 0.90 | (0.52, 1.55) | 1.06 | (0.57, 1.99) | 1.03 | (0.52, 2.06) |
Serum albumin (g/dl) | ||||||||
 < 3.20 | 0.91 | (0.49, 1.67) | 0.82 | (0.46, 1.46) | 1.26 | (0.69, 2.29) | 1.22 | (0.69, 2.15) |
 3.20–3.49 | 1.17 | (0.74, 1.85) | 1.10 | (0.67, 1.80) | 0.98 | (0.57, 1.68) | 0.96 | (0.55, 1.67) |
 3.50–3.79 | 1.14 | (0.81, 1.61) | 1.16 | (0.81, 1.66) | 1.08 | (0.75, 1.54) | 1.19 | (0.80, 1.76) |
 3.80+ | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
Phosphate binder use | ||||||||
 None | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 Ca-containing only | 0.60 | (0.28, 1.31) | 0.51 | (0.25, 1.08) | 0.75 | (0.38, 1.51) | 0.54 | (0.27, 1.08) |
 Non-Ca-containing only | 0.97 | (0.62, 1.54) | 0.91 | (0.58, 1.44) | 1.00 | (0.65, 1.56) | 0.94 | (0.60, 1.49) |
 Both | 0.97 | (0.56, 1.69) | 0.79 | (0.45, 1.40) | 0.79 | (0.44, 1.40) | 0.64 | (0.36, 1.13) |
Vitamin D use | ||||||||
 None | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 IV vitamin D only | 0.95 | (0.66, 1.38) | 1.00 | (0.66, 1.51) | 1.30 | (0.91, 1.85) | 1.36 | (0.91, 2.03) |
 Oral vitamin D only | 0.76 | (0.51, 1.15) | 0.83 | (0.56, 1.22) | 1.17 | (0.76, 1.79) | 1.12 | (0.70, 1.79) |