| Baseline | Time-dependent | ||||||
---|---|---|---|---|---|---|---|---|
Crude | Adjusteda | Crude | Adjusted a | |||||
Variable | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI |
Age (yrs) | ||||||||
 < 45 | 0.91 | (0.53, 1.54) | 0.87 | (0.49, 1.54) |  |  |  |  |
 45–54 | 0.90 | (0.57, 1.42) | 1.01 | (0.60, 1.71) |  |  |  |  |
 55–64 | 1 | (ref) | 1 | (ref) |  |  |  |  |
 65–74 | 0.98 | (0.64, 1.51) | 0.96 | (0.58, 1.61) |  |  |  |  |
 75+ | 1.05 | (0.71, 1.56) | 0.93 | (0.59, 1.45) |  |  |  |  |
Vintage (yrs) | ||||||||
 < 1.0 | 1.35 | (0.74, 2.46) | 1.70 | (0.86, 3.37) |  |  |  |  |
 1.0–2.9 | 1 | (ref) | 1 | (ref) |  |  |  |  |
 3.0–4.9 | 1.17 | (0.76, 1.80) | 1.26 | (0.77, 2.07) |  |  |  |  |
 5.0+ | 1.23 | (0.79, 1.92) | 1.25 | (0.76, 2.05) |  |  |  |  |
BMI (kg/m2) | ||||||||
 < 18.5 | 1.20 | (0.54, 2.65) | 1.21 | (0.54, 2.71) |  |  |  |  |
 18.5–24.9 | 1.21 | (0.82, 1.78) | 1.19 | (0.79, 1.79) |  |  |  |  |
 25.0–29.9 | 1 | (ref) | 1 | (ref) |  |  |  |  |
 30.0+ | 1.00 | (0.69, 1.46) | 1.08 | (0.71, 1.63) |  |  |  |  |
Male sex | 0.90 | (0.68, 1.19) | 0.84 | (0.58, 1.22) | Â | Â | Â | Â |
Coronary artery disease | 0.95 | (0.67, 1.34) | 0.90 | (0.59, 1.38) | Â | Â | Â | Â |
Cancer | 1.32 | (0.86, 2.04) | 1.28 | (0.78, 2.09) | Â | Â | Â | Â |
Other cardiovascular disease | 0.96 | (0.72, 1.30) | 0.98 | (0.70, 1.35) | Â | Â | Â | Â |
Cerebrovascular disease | 1.23 | (0.78, 1.94) | 1.18 | (0.69, 2.00) | Â | Â | Â | Â |
Congestive heart failure | 0.96 | (0.61, 1.51) | 0.99 | (0.58, 1.69) | Â | Â | Â | Â |
Diabetes | 0.92 | (0.65, 1.29) | 0.99 | (0.69, 1.41) | Â | Â | Â | Â |
GI bleeding | 0.89 | (0.45, 1.78) | 0.94 | (0.41, 2.16) | Â | Â | Â | Â |
Hypertension | 1.06 | (0.72, 1.56) | 1.23 | (0.79, 1.90) | Â | Â | Â | Â |
Lung disease | 0.77 | (0.51, 1.18) | 0.73 | (0.45, 1.19) | Â | Â | Â | Â |
Psychiatric disorder | 0.92 | (0.62, 1.35) | 0.94 | (0.63, 1.41) | Â | Â | Â | Â |
Peripheral vascular disease | 1.11 | (0.80, 1.54) | 1.21 | (0.83, 1.75) | Â | Â | Â | Â |
Hospitalization in prior 3 months | 0.83 | (0.54, 1.28) | 0.76 | (0.45, 1.30) | 0.77 | (0.52, 1.14) | 0.82 | (0.54, 1.24) |
Serum phosphorus (mg/dl) | ||||||||
 < 3.50 | 0.86 | (0.58, 1.28) | 0.84 | (0.54, 1.31) | 0.40 | (0.24, 0.67) | 0.40 | (0.24, 0.66) |
 3.50–5.49 | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 5.50–5.99 | 0.75 | (0.41, 1.36) | 0.68 | (0.40, 1.18) | 1.42 | (0.91, 2.24) | 1.27 | (0.85, 1.89) |
 6.00+ | 1.06 | (0.76, 1.49) | 1.03 | (0.72, 1.49) | 1.01 | (0.69, 1.49) | 1.05 | (0.70, 1.56) |
Serum PTH (pg/ml) | ||||||||
 < 150 | 0.90 | (0.60, 1.33) | 0.87 | (0.54, 1.41) | 1.35 | (0.80, 2.27) | 1.39 | (0.84, 2.31) |
 150–299 | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 300–599 | 1.26 | (0.81, 1.96) | 1.39 | (0.84, 2.31) | 1.77 | (1.15, 2.71) | 1.88 | (1.19, 2.97) |
 600+ | 1.19 | (0.75, 1.87) | 1.23 | (0.72, 2.09) | 2.99 | (1.91, 4.69) | 3.02 | (1.92, 4.76) |
Serum calcium (mg/dl) | ||||||||
 < 7.50 | 0.60 | (0.17, 2.11) | 0.66 | (0.18, 2.38) | 0.51 | (0.17, 1.51) | 0.49 | (0.15, 1.62) |
 7.50–8.39 | 1.13 | (0.78, 1.63) | 1.15 | (0.78, 1.70) | 1.05 | (0.70, 1.56) | 1.03 | (0.67, 1.58) |
 8.40–10.19 | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 10.20+ | 2.06 | (1.32, 3.20) | 2.04 | (1.28, 3.25) | 1.26 | (0.84, 1.88) | 1.24 | (0.80, 1.93) |
Serum albumin (g/dl) | ||||||||
 < 3.20 | 0.64 | (0.40, 1.02) | 0.61 | (0.36, 1.02) | 0.51 | (0.30, 0.87) | 0.49 | (0.26, 0.92) |
 3.20–3.49 | 0.70 | (0.44, 1.10) | 0.60 | (0.37, 0.98) | 0.98 | (0.67, 1.43) | 0.97 | (0.66, 1.43) |
 3.50–3.79 | 0.90 | (0.66, 1.24) | 0.89 | (0.63, 1.25) | 0.96 | (0.67, 1.37) | 0.95 | (0.64, 1.39) |
 3.80+ | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
Phosphate binder use | ||||||||
 None | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 Ca-containing only | 1.02 | (0.59, 1.75) | 1.21 | (0.68, 2.15) | 0.90 | (0.55, 1.48) | 0.91 | (0.53, 1.54) |
 Non-Ca-containing only | 1.30 | (0.83, 2.04) | 1.37 | (0.82, 2.28) | 1.55 | (1.07, 2.24) | 1.50 | (1.06, 2.12) |
 Both | 1.15 | (0.72, 1.85) | 1.22 | (0.69, 2.15) | 1.19 | (0.75, 1.89) | 1.20 | (0.72, 1.99) |
Vitamin D use | ||||||||
 None | 1 | (ref) | 1 | (ref) | 1 | (ref) | 1 | (ref) |
 IV vitamin D only | 1.05 | (0.72, 1.53) | 0.95 | (0.64, 1.43) | 0.91 | (0.61, 1.35) | 0.87 | (0.57, 1.33) |
 Oral vitamin D only | 1.16 | (0.81, 1.67) | 1.06 | (0.75, 1.50) | 1.01 | (0.71, 1.43) | 0.94 | (0.67, 1.31) |
 Both | 0.86 | (0.37, 2.02) | 0.97 | (0.46, 2.02) | 0.61 | (0.18, 2.08) | 0.70 | (0.21, 2.30) |