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Table 4 Estimated effects (crude and adjusted hazard ratios [HR] and 95% confidence intervals [CI]) of patient predictors on cinacalcet reinitiation, by type of predictor (baseline or time-dependent), in the newly-discontinued-user cohort (n = 415)

From: Predictors of cinacalcet discontinuation and reinitiation in hemodialysis patients: results from 7 European countries

 

Baseline

Time-dependent

Crude

Adjusteda

Crude

Adjusted a

Variable

HR

95% CI

HR

95% CI

HR

95% CI

HR

95% CI

Age (yrs)

 < 45

0.91

(0.53, 1.54)

0.87

(0.49, 1.54)

    

 45–54

0.90

(0.57, 1.42)

1.01

(0.60, 1.71)

    

 55–64

1

(ref)

1

(ref)

    

 65–74

0.98

(0.64, 1.51)

0.96

(0.58, 1.61)

    

 75+

1.05

(0.71, 1.56)

0.93

(0.59, 1.45)

    

Vintage (yrs)

 < 1.0

1.35

(0.74, 2.46)

1.70

(0.86, 3.37)

    

 1.0–2.9

1

(ref)

1

(ref)

    

 3.0–4.9

1.17

(0.76, 1.80)

1.26

(0.77, 2.07)

    

 5.0+

1.23

(0.79, 1.92)

1.25

(0.76, 2.05)

    

BMI (kg/m2)

 < 18.5

1.20

(0.54, 2.65)

1.21

(0.54, 2.71)

    

 18.5–24.9

1.21

(0.82, 1.78)

1.19

(0.79, 1.79)

    

 25.0–29.9

1

(ref)

1

(ref)

    

 30.0+

1.00

(0.69, 1.46)

1.08

(0.71, 1.63)

    

Male sex

0.90

(0.68, 1.19)

0.84

(0.58, 1.22)

    

Coronary artery disease

0.95

(0.67, 1.34)

0.90

(0.59, 1.38)

    

Cancer

1.32

(0.86, 2.04)

1.28

(0.78, 2.09)

    

Other cardiovascular disease

0.96

(0.72, 1.30)

0.98

(0.70, 1.35)

    

Cerebrovascular disease

1.23

(0.78, 1.94)

1.18

(0.69, 2.00)

    

Congestive heart failure

0.96

(0.61, 1.51)

0.99

(0.58, 1.69)

    

Diabetes

0.92

(0.65, 1.29)

0.99

(0.69, 1.41)

    

GI bleeding

0.89

(0.45, 1.78)

0.94

(0.41, 2.16)

    

Hypertension

1.06

(0.72, 1.56)

1.23

(0.79, 1.90)

    

Lung disease

0.77

(0.51, 1.18)

0.73

(0.45, 1.19)

    

Psychiatric disorder

0.92

(0.62, 1.35)

0.94

(0.63, 1.41)

    

Peripheral vascular disease

1.11

(0.80, 1.54)

1.21

(0.83, 1.75)

    

Hospitalization in prior 3 months

0.83

(0.54, 1.28)

0.76

(0.45, 1.30)

0.77

(0.52, 1.14)

0.82

(0.54, 1.24)

Serum phosphorus (mg/dl)

 < 3.50

0.86

(0.58, 1.28)

0.84

(0.54, 1.31)

0.40

(0.24, 0.67)

0.40

(0.24, 0.66)

 3.50–5.49

1

(ref)

1

(ref)

1

(ref)

1

(ref)

 5.50–5.99

0.75

(0.41, 1.36)

0.68

(0.40, 1.18)

1.42

(0.91, 2.24)

1.27

(0.85, 1.89)

 6.00+

1.06

(0.76, 1.49)

1.03

(0.72, 1.49)

1.01

(0.69, 1.49)

1.05

(0.70, 1.56)

Serum PTH (pg/ml)

 < 150

0.90

(0.60, 1.33)

0.87

(0.54, 1.41)

1.35

(0.80, 2.27)

1.39

(0.84, 2.31)

 150–299

1

(ref)

1

(ref)

1

(ref)

1

(ref)

 300–599

1.26

(0.81, 1.96)

1.39

(0.84, 2.31)

1.77

(1.15, 2.71)

1.88

(1.19, 2.97)

 600+

1.19

(0.75, 1.87)

1.23

(0.72, 2.09)

2.99

(1.91, 4.69)

3.02

(1.92, 4.76)

Serum calcium (mg/dl)

 < 7.50

0.60

(0.17, 2.11)

0.66

(0.18, 2.38)

0.51

(0.17, 1.51)

0.49

(0.15, 1.62)

 7.50–8.39

1.13

(0.78, 1.63)

1.15

(0.78, 1.70)

1.05

(0.70, 1.56)

1.03

(0.67, 1.58)

 8.40–10.19

1

(ref)

1

(ref)

1

(ref)

1

(ref)

 10.20+

2.06

(1.32, 3.20)

2.04

(1.28, 3.25)

1.26

(0.84, 1.88)

1.24

(0.80, 1.93)

Serum albumin (g/dl)

 < 3.20

0.64

(0.40, 1.02)

0.61

(0.36, 1.02)

0.51

(0.30, 0.87)

0.49

(0.26, 0.92)

 3.20–3.49

0.70

(0.44, 1.10)

0.60

(0.37, 0.98)

0.98

(0.67, 1.43)

0.97

(0.66, 1.43)

 3.50–3.79

0.90

(0.66, 1.24)

0.89

(0.63, 1.25)

0.96

(0.67, 1.37)

0.95

(0.64, 1.39)

 3.80+

1

(ref)

1

(ref)

1

(ref)

1

(ref)

Phosphate binder use

 None

1

(ref)

1

(ref)

1

(ref)

1

(ref)

 Ca-containing only

1.02

(0.59, 1.75)

1.21

(0.68, 2.15)

0.90

(0.55, 1.48)

0.91

(0.53, 1.54)

 Non-Ca-containing only

1.30

(0.83, 2.04)

1.37

(0.82, 2.28)

1.55

(1.07, 2.24)

1.50

(1.06, 2.12)

 Both

1.15

(0.72, 1.85)

1.22

(0.69, 2.15)

1.19

(0.75, 1.89)

1.20

(0.72, 1.99)

Vitamin D use

 None

1

(ref)

1

(ref)

1

(ref)

1

(ref)

 IV vitamin D only

1.05

(0.72, 1.53)

0.95

(0.64, 1.43)

0.91

(0.61, 1.35)

0.87

(0.57, 1.33)

 Oral vitamin D only

1.16

(0.81, 1.67)

1.06

(0.75, 1.50)

1.01

(0.71, 1.43)

0.94

(0.67, 1.31)

 Both

0.86

(0.37, 2.02)

0.97

(0.46, 2.02)

0.61

(0.18, 2.08)

0.70

(0.21, 2.30)

  1. aAdjusted for baseline covariates: age, vintage, 13 summary comorbid conditions, body mass index, and male sex. Separate models estimated for each variable shown. Time-dependent effects estimated only for variables shown. Psychiatric disorder includes depression, bipolar disorder, schizophrenia, and alcohol or substance abuse