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Table 1 Characteristics of kidney transplant (KT) candidates by race

From: Racial differences in inflammation and outcomes of aging among kidney transplant candidates

Characteristics

Non-African American

African American

p value

n = 589, 58.7%

n = 414, 41.3%

Age, yearsa

56.2 (13.4)

52.9 (12.9)

< 0.001

Female, %

36.0

38.4

0.44

Charlson comorbidity indexa

2.0 (2.5)

2.1 (2.2)

0.50

Comorbidities, %

 Myocardial infarction

12.1

9.9

0.28

 Peripheral vascular disease

9.0

6.0

0.09

 Cerebral vascular disease

8.0

9.0

0.59

 Dementia

0.9

0.7

0.83

 Chronic lung disease

4.5

3.4

0.41

 Rheumatologic disease

5.5

8.1

0.10

 Peptic ulcer disease

3.8

2.2

0.16

 Diabetes

40.7

49.2

0.008

 Diabetes with complications

26.2

26.9

0.82

 Moderate/severe liver disease

3.3

5.6

0.07

 Metastatic cancer

0.9

0.7

0.82

 Leukemia

0.9

0.2

0.22

 Lymphoma

1.2

0.5

0.24

 Congestive heart failure

14.3

14.3

1.00

 HIV+

0.9

8.7

< 0.001

Dialysis type

< 0.001

 No dialysis

43.2

26.2

 

 Hemodialysis

45.1

61.9

 Peritoneal dialysis

11.8

11.9

Time on dialysis

< 0.001

 0 year

48.2

29.0

 

 1 or 2 years

32.4

38.6

 

 More than 2 years

19.4

32.4

 

Inflammatory Markerb

 IL-6, pg/ml

4.5 [2.8–8.4]

4.3 [2.8–8.1]

0.95

 TNFR1, ng/ml

9.7 [5.8–17.7]

14.0 [7.8–20.5]

< 0.001

 CRP, ug/ml

4.7 [1.9–10.2]

4.9 [2.2–11.0]

0.36

 Inflammatory Index

6.7 [6.2–7.1]

6.8 [6.5–7.2]

< 0.001

Frail status, %

0.01

 Nonfrail

55.2

48.3

 

 Intermediate Frail

28.7

28.3

 

 Frail

16.1

23.4

 

SPPB impairment, %

36.3

46.0

0.003

Fair/Poor HRQOL, %

48.0

50.9

0.37

  1. amean (standard deviation)
  2. bmedian [IQR]
  3. SPPB Short Physical Performance Battery, HRQOL Health Related Quality of Life, IL-6 Interleukin-6, TNFR1 tumor necrosis factor-α receptor-1, CRP C-reactive protein
  4. The aggregate inflammatory index consists of IL-6 and TNFR1