From: Racial differences in inflammation and outcomes of aging among kidney transplant candidates
Characteristics | Non-African American | African American | p value |
---|---|---|---|
n = 589, 58.7% | n = 414, 41.3% | ||
Age, yearsa | 56.2 (13.4) | 52.9 (12.9) | < 0.001 |
Female, % | 36.0 | 38.4 | 0.44 |
Charlson comorbidity indexa | 2.0 (2.5) | 2.1 (2.2) | 0.50 |
Comorbidities, % | |||
 Myocardial infarction | 12.1 | 9.9 | 0.28 |
 Peripheral vascular disease | 9.0 | 6.0 | 0.09 |
 Cerebral vascular disease | 8.0 | 9.0 | 0.59 |
 Dementia | 0.9 | 0.7 | 0.83 |
 Chronic lung disease | 4.5 | 3.4 | 0.41 |
 Rheumatologic disease | 5.5 | 8.1 | 0.10 |
 Peptic ulcer disease | 3.8 | 2.2 | 0.16 |
 Diabetes | 40.7 | 49.2 | 0.008 |
 Diabetes with complications | 26.2 | 26.9 | 0.82 |
 Moderate/severe liver disease | 3.3 | 5.6 | 0.07 |
 Metastatic cancer | 0.9 | 0.7 | 0.82 |
 Leukemia | 0.9 | 0.2 | 0.22 |
 Lymphoma | 1.2 | 0.5 | 0.24 |
 Congestive heart failure | 14.3 | 14.3 | 1.00 |
 HIV+ | 0.9 | 8.7 | < 0.001 |
Dialysis type | < 0.001 | ||
 No dialysis | 43.2 | 26.2 |  |
 Hemodialysis | 45.1 | 61.9 | |
 Peritoneal dialysis | 11.8 | 11.9 | |
Time on dialysis | < 0.001 | ||
 0 year | 48.2 | 29.0 |  |
 1 or 2 years | 32.4 | 38.6 |  |
 More than 2 years | 19.4 | 32.4 |  |
Inflammatory Markerb | |||
 IL-6, pg/ml | 4.5 [2.8–8.4] | 4.3 [2.8–8.1] | 0.95 |
 TNFR1, ng/ml | 9.7 [5.8–17.7] | 14.0 [7.8–20.5] | < 0.001 |
 CRP, ug/ml | 4.7 [1.9–10.2] | 4.9 [2.2–11.0] | 0.36 |
 Inflammatory Index | 6.7 [6.2–7.1] | 6.8 [6.5–7.2] | < 0.001 |
Frail status, % | 0.01 | ||
 Nonfrail | 55.2 | 48.3 |  |
 Intermediate Frail | 28.7 | 28.3 |  |
 Frail | 16.1 | 23.4 |  |
SPPB impairment, % | 36.3 | 46.0 | 0.003 |
Fair/Poor HRQOL, % | 48.0 | 50.9 | 0.37 |