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Table 2 Association between inflammatory markers and adverse health outcomes of aging (frailty, SPPB impairment, and poor HRQOL) by race

From: Racial differences in inflammation and outcomes of aging among kidney transplant candidates

Outcome

Inflammatory Marker

Race

RR (95% CI)

Interaction p value

aRR (95% CI)

Interaction p value

Frailty

IL-6

Non-AA

1.63 (1.36, 1.94)

0.05

1.58 (1.27, 1.96)

0.04

AA

1.27 (1.08, 1.51)

1.18 (0.99, 1.41)

TNFR1

Non-AA

1.39 (1.19, 1.62)

0.02

1.60 (1.25, 2.05)

0.02

AA

1.04 (0.87, 1.25)

1.18 (0.92, 1.51)

CRP

Non-AA

1.44 (1.15, 1.81)

0.08

1.41 (1.10, 1.82)

0.1

AA

1.11 (0.91, 1.37)

1.11 (0.92, 1.33)

Inf. Index

Non-AA

1.60 (1.35, 1.89)

0.01

1.82 (1.44, 2.31)

< 0.01

AA

1.17 (0.97, 1.40)

1.26 (1.02, 1.56)

SPPB impairment

IL-6

Non-AA

1.56 (1.41, 1.72)

0.01

1.49 (1.33, 1.67)

< 0.01

AA

1.28 (1.15, 1.42)

1.20 (1.08, 1.32)

TNFR1

Non-AA

1.26 (1.14, 1.40)

0.03

1.47 (1.27, 1.71)

< 0.01

AA

1.07 (0.95, 1.20)

1.17 (1.01, 1.36)

CRP

Non-AA

1.35 (1.21, 1.53)

0.03

1.32 (1.16, 1.49)

0.09

AA

1.13 (1.01, 1.27)

1.14 (1.02, 1.27)

Inf. Index

Non-AA

1.45 (1.31, 1.61)

0.01

1.67 (1.48, 1.90)

< 0.001

AA

1.19 (1.06, 1.34)

1.28 (1.13, 1.46)

Fair/Poor HRQOL

IL-6

Non-AA

1.16 (1.07, 1.27)

0.01

1.19 (1.09, 1.29)

< 0.001

AA

0.99 (0.89, 1.09)

0.96 (0.87, 1.06)

TNFR1

Non-AA

1.02 (0.94, 1.11)

< 0.01

1.06 (0.95, 1.19)

< 0.01

AA

0.84 (0.77, 0.93)

0.88 (0.78, 1.00)

CRP

Non-AA

1.16 (1.06, 1.27)

0.01

1.18 (1.08, 1.30)

< 0.01

AA

0.98 (0.89, 1.07)

0.99 (0.91, 1.09)

Inf. Index

Non-AA

1.09 (1.00, 1.18)

0.001

1.16 (1.05, 1.29)

< 0.001

AA

0.87 (0.78, 0.96)

0.92 (0.82, 1.03)

  1. Modified Poisson regression models were adjusted for age, sex, CCI, dialysis type, and time on dialysis/dialysis vintage. Interaction p value marks the difference between Non-African American (non-AA) and African American (AA) participants
  2. SPPB Short Physical Performance Battery, HRQOL Health Related Quality of Life, IL-6 Interleukin-6, TNFR1 tumor necrosis factor-α receptor-1, CRP C-reactive protein, aRR adjusted relative risk RR: relative risk
  3. The aggregate inflammatory index consists of IL-6 and TNFR1