Fig. 3

Angptl3 knockout protects the ultrastructure of podocytes. Representative kidney ultrastructure observed with a TEM (a) and the quantification of foot process width (b) and number (c) of Angptl3+/+ and Angptl3−/− mice treated with or without ADR injection (10,000 ×; scale bars = 1 μm; red frames indicate podocyte foot process effacement; arrows indicate podocyte microvillus transformation; arrowheads indicate foot process detachment). Data are shown as the mean ± SEM; * P < 0.05 and ** P < 0.01