Fig. 4

Angptl3 knockout reduces cell loss in renal glomeruli of mice with glomerulosclerosis. a Detached cells in Bowman’s capsule of Angptl3+/+ and Angptl3−/− mice treated with ADR injection for 12 weeks. The detached cells in Bowman’s capsule were analyzed under a light microscope and TEM. (PAS staining image with 400 × magnification, scale bars = 5 μm, 30 glomeruli from each mouse, 6 mice per group; transmission electron microscopy image with × 25,000 magnification, scale bars = 1 μm, 1 glomeruli from each mouse, 6 mice per group). b Apoptotic cells in glomeruli of Angptl3+/+ and Angptl3−/− mice treated with ADR injection for 12 weeks (630 ×, scale bars = 5 μm, 30 glomeruli from each mouse, 6 mice per group). Data are shown as the mean ± SEM; * P < 0.05 and ** P < 0.01