Fig. 5

Angptl3 knockout alleviates the loss of podocytes from glomeruli to the urine in the ADR nephropathy mouse model. a Podocyte density in glomeruli of Angptl3+/+ and Angptl3−/− mice treated with or without ADR injection for 12 weeks detected by immunofluorescence staining for the podocyte-specific markers nephrin and podocin and confocal microscopy (630 ×, scale bars = 5 μm, n = 9). The mRNA levels of the podocyte-specific markers nephrin (b) and podocin (c) in the urine of Angptl3+/+ and Angptl3−/− mice treated with ADR injection from week 1 to week 12. Data are shown as the mean ± SEM; n = 6 per group; * P < 0.05