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Table 3 Stepwise Cox regression modeled analysis for associations between low Klotho levels and the occurrence of the primary endpoint (all-cause death or myocardial infarction or stroke)

From: Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis

  Klotho
HR (95% CIs)
For the low klotho group
P value
Model 1 2.137 (1.124–4.065) 0.021
Model 2 2.081 (1.093–3.960) 0.026
Model 3 2.089 (1.097–3.976) 0.025
Model 4 2.090 (1.096–3.984) 0.025
Model 5 2.476 (1.184–5.178) 0.016
Model 6 2.759 (1.223–6.224) 0.014
  1. Model 1: Unadjusted; Model 2: Adjusted for cFGF-23; Model 3: Adjusted for cFGF-23 and iPTH; Model 4: Adjusted for cFGF-23, iPTH and Ca x P; Model 5: Adjusted for cFGF-23, iPTH, Ca x P, age, hemodialysis vintage and history of diabetes mellitus, cardiovascular disease (defined as history of coronary heart disease, stroke and/or peripheral vascular disease), hypertension and smoking; Model 6: Adjusted for cFGF-23, iPTH, Ca x P, age, hemodialysis vintage and history of diabetes mellitus, cardiovascular disease (defined as history of coronary heart disease, stroke and/or peripheral vascular disease), hypertension, smoking, cfPWV and ccIMT
  2. Abbreviations: Ca x P Calcium x phosphorus product, ccIMT Common carotid Intima Media Thickness, CI Confidence intervals, HR Hazard ratio, cFGF-23 c-terminal Fibroblast Growth Factor 23, cfPWV Carotid - femoral Pulse Wave Velocity, iPTH Intact parathormone