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Table 3 Stepwise Cox regression modeled analysis for associations between low Klotho levels and the occurrence of the primary endpoint (all-cause death or myocardial infarction or stroke)

From: Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis

 

Klotho

HR (95% CIs)

For the low klotho group

P value

Model 1

2.137 (1.124–4.065)

0.021

Model 2

2.081 (1.093–3.960)

0.026

Model 3

2.089 (1.097–3.976)

0.025

Model 4

2.090 (1.096–3.984)

0.025

Model 5

2.476 (1.184–5.178)

0.016

Model 6

2.759 (1.223–6.224)

0.014

  1. Model 1: Unadjusted; Model 2: Adjusted for cFGF-23; Model 3: Adjusted for cFGF-23 and iPTH; Model 4: Adjusted for cFGF-23, iPTH and Ca x P; Model 5: Adjusted for cFGF-23, iPTH, Ca x P, age, hemodialysis vintage and history of diabetes mellitus, cardiovascular disease (defined as history of coronary heart disease, stroke and/or peripheral vascular disease), hypertension and smoking; Model 6: Adjusted for cFGF-23, iPTH, Ca x P, age, hemodialysis vintage and history of diabetes mellitus, cardiovascular disease (defined as history of coronary heart disease, stroke and/or peripheral vascular disease), hypertension, smoking, cfPWV and ccIMT
  2. Abbreviations: Ca x P Calcium x phosphorus product, ccIMT Common carotid Intima Media Thickness, CI Confidence intervals, HR Hazard ratio, cFGF-23 c-terminal Fibroblast Growth Factor 23, cfPWV Carotid - femoral Pulse Wave Velocity, iPTH Intact parathormone
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BMC Nephrology

ISSN: 1471-2369

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