Skip to main content

Table 2 Marginal mean change in BMI (Multivariate mixed effect model) between Indigenous and Non-Indigenous groups with confounders

From: Weight change trajectories in Aboriginal and Torres Strait islander Australians after kidney transplantation: a cohort analysis using the Australia and New Zealand Dialysis and Transplant registry (ANZDATA)

Variables

Univariate Model [1]

Multivariate Model 12

Multivariate Model 23

Coefficient [4] (95% CI)

RE % [5]

P value

Coefficient4 (95% CI)

RE % [5]

P value

Coefficient4 (95% CI)

RE % [5]

P value

Indigenous status

 Non-indigenous

Reference

–

–

Reference

–

–

Reference

–

–

 Indigenous

0.06 (− 0.18–0.30)

6.2

0.618

− 0.05 (− 0.29–0.19)

−4.9

0.687

−0.04 (− 0.32–0.23)

−4.1

0.765

Time post-transplant (months)

 0

Reference

–

–

Reference

–

–

Reference

–

–

 3

0.29 (0.24–0.35)

34.2

< 0.001

0.30 (0.24–0.35)

34.7

< 0.001

0.33 (0.27–0.39)

39.2

< 0.001

 6

0.80 (0.75–0.86)

123.2

< 0.001

0.81 (0.75–0.86)

123.9

< 0.001

0.84 (0.78–0.90)

132.6

< 0.001

 12

1.23 (1.18–1.29)

243.1

< 0.001

1.24 (1.18–1.29)

243.1

< 0.001

1.26 (1.20–1.32)

251.4

< 0.001

 24

1.46 (1.40–1.51)

328.7

< 0.001

1.46 (1.40–1.52)

328.7

< 0.001

1.48 (1.41–1.54)

337.6

< 0.001

BMI at time of transplantation

0.95 (0.94–0.96)

159.5

< 0.001

0.96 (0.96–0.97)

159.5

< 0.001

0.97 (0.96–0.98)

162.8

< 0.001

Indigenous status x time (months)

 post-transplant (interaction) [6]

        

–

  Indigenous and 3

0.02 (−0.23–0.26)

1.7

0.894

0.01 (−0.24–0.26)

0.8

0.950

− 0.003 (− 0.27–0.26)

−0.3

0.98

  Indigenous and 6

0.28 (0.03–0.53)

32.5

0.029

0.27 (0.02–0.53)

31.4

0.034

0.34 (0.07–0.61)

40.9

0.012

  Indigenous and 12

0.60 (0.34–0.86)

81.8

< 0.001

0.59 (0.33–0.85)

80.5

< 0.001

0.61 (0.34–0.88)

84.1

< 0.001

  Indigenous and 24

0.44 (0.16–0.72)

55.0

< 0.01

0.43 (0.15–0.71)

54.0

< 0.01

0.45 (0.16–0.74)

57.1

< 0.01

Recipient age, years

   

−0.03 (− 0.033--.026)

−2.9

< 0.001

− 0.03 (− 0.04--0.03)

−3.1

< 0.001

Gender

 Male

   

Reference

–

–

Reference

–

–

 Female

   

0.20 (0.11–0.28)

21.9

< 0.001

0.21 (0.12–0.31)

23.6

< 0.001

Current smoking status

 No

   

Reference

–

–

Reference

–

–

 Yes

   

0.09 (−0.03–0.21)

9.5

0.151

0.08 (− 0.05–0.21)

8.3

0.245

Diabetes Mellitus

 No

   

Reference

–

–

Reference

–

–

 Yes

   

0.02 (−0.10–0.14)

2.0

0.748

0.01 (−0.12–0.15)

1.4

0.845

Coronary artery disease

 No

   

Reference

–

–

Reference

–

–

 Yes

   

0.17 (0.05–0.29)

18.6

< 0.01

0.18 (0.05–0.32)

20.1

< 0.01

Cerebrovascular disease

 No

   

Reference

–

–

Reference

–

–

 Yes

   

−0.16 (−0.35–0.03)

−14.7

0.095

−0.18 (− 0.39–0.03)

−16.2

0.096

Peripheral vascular disease

 No

   

Reference

–

–

Reference

–

–

 Yes

   

−0.04 (−0.20–0.11)

−4.2

0.585

−0.05 (− 0.22–0.13)

−4.5

0.600

Total ischemia time

   

−0.02 (− 0.03--.01)

− 1.8

< 0.001

− 0.02 (− 0.03–0.02)

−1.7

< 0.001

HLA antigen mismatch

   

− 0.02 (− 0.04–0.01)

−1.6

0.222

−0.01 (− 0.04–0.02)

−1.1

0.422

Dialysis vintage

 Pre-emptive

   

Reference

–

–

Reference

–

–

 < 1 year

   

−0.01 (−0.82–0.79)

−1.2

0.977

0.01 (−0.87–0.89)

1.2

0.978

 1–5 years

   

−0.04 (− 0.84–0.75)

−4.4

0.912

−0.01 (− 0.89–0.86)

−1.1

0.980

 > 5 years

   

−0.14 (− 0.94–0.66)

−12.8

0.737

−0.09 (− 0.97–0.79)

−8.3

0.846

Transplantation era

 1995–1999

   

Reference

–

–

Reference

–

–

 2000–2004

   

−0.05 (−0.18–0.07)

−5.2

0.415

−0.08 (− 0.22–0.05)

− 8.0

0.235

 2005–2009

   

0.07 (−0.06–0.20)

7.4

0.283

0.04 (−0.10–0.18)

4.2

0.570

 2010–2014

   

0.14 (0.01–0.27)

15.2

0.029

0.12 (−0.03–0.26)

12.3

0.121

Donor age

   

−0.01 (− 0.01--0.004)

−0.7

< 0.001

− 0.01 (− 0.01--0.004)

−0.7

< 0.001

Donor gender

 Male

   

Reference

–

–

Reference

–

–

 Female

   

0.02 (−0.06–0.10)

1.9

0.663

0.02 (−0.07–0.11)

2.1

0.651

Rejection

 No

      

Reference

–

–

 Yes

      

−0.10 (−0.20–0.004)

−9.6

0.058

Delayed graft function

 No

      

Reference

–

–

 Yes

      

−0.17 (− 0.28--0.05)

−15.3

< 0.001

Prednisolone doses quarterly (mg)

 0

      

−0.26 (− 0.44--0.09)

−22.9

< 0.001

 1–4.99 mg

      

0.20 (−0.03–0.43)

29.7

0.08

 5–6.99 mg

      

Reference

–

–

 7–9.99 mg

      

−0.03 (−0.16–0.09)

−3.0

0.59

 10+ mg

      

−0.11 (− 0.22–0.01)

−10.4

0.06

Constant/intercept

1.22 (0.98–1.46)

< 0.001

–

2.87 (2.02–3.73)

–

< 0.001

2.74 (1.80–3.69)

–

< 0.001

  1. 1. Univariate model includes indigenous status, time post transplants and interaction between indigenous status and time post transplants
  2. 2. Multivariate model 1 includes variables from model 1 plus recipient’s age, gender, smoking status, diabetes mellitus, comorbidities, ischemia time, HLA mismatches, dialysis vintage, transplant ERA, Donor’s age and gender
  3. 3. Multivariate model 2 includes variables from multivariate model 1 plus rejection, delayed graft function, and prednisolone doses
  4. 4. Marginal mean change in BMI (kg/m2)
  5. 5. RE% corresponding to a coefficient expressed as expected percentage change in BMI, calculated as (exp(coefficient)-1)*100
  6. 6. In addition to main effects (indigenous status and time), the interaction term (indigenous status x time) explains the BMI change between Indigenous and non-indigenous groups by different times post transplants
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us