From: Early outcomes of kidney transplantation from elderly donors after circulatory death (GEODAS study)
Donor ≤65 years (n = 426) | Donor > 65 years (n = 135) | p-value | |
---|---|---|---|
Recipient characteristics | |||
Age (years, mean (SD)) | 53.7 (11.4) | 65.8 (8.8) | < 0.001 |
Age > 65 years (%) | 14.6 | 61.3 | < 0.001 |
Female Gender (%) | 30.1 | 35.6 | 0.23 |
Black Race (%) | 1.4 | 0.7 | 0.5 |
Diabetes mellitus (%) | 26.1 | 51.4 | < 0.001 |
Previous cardiovascular eventa (%) | 7.8 | 20.7 | < 0.001 |
Cause of end-stage renal disease (%) | |||
Hypertensive nephropathy | 12.4 | 11.9 | |
Diabetic nephropathy | 11.3 | 22.2 | |
Glomerulonephritis | 19.0 | 12.6 | |
Interstitial | 11.0 | 11.9 | 0.03 |
Polycystic | 15.3 | 11.1 | |
Others | 6.7 | 5.9 | |
Unknown | 19.7 | 23.7 | |
Previous renal replacement therapy (%) | |||
Hemodialysis | 73.1 | 83.0 | |
Peritoneal Dialysis | 21.0 | 14.8 | 0.05 |
Preemptive kidney transplant | 5.9 | 2.2 | |
Dialysis vintage (years, median [IQR]) | 1.1 [2.0–3.6] | 1.3 [2.6–4.0] | 0.08 |
Patients with previous kidney transplant (%) | 8.4 | 7.4 | 0.7 |
Donor characteristics | |||
Age (years, mean (SD)) | 52.7 (9.1) | 72.0 (4.9) | < 0.001 |
Female Gender (%) | 26.3 | 45.9 | < 0.001 |
Expanded criteria donors (%) | 29.3 | 100 | < 0.001 |
Stroke as Cause of death (%) | 49.2 | 67.8 | < 0.001 |
Transplant characteristics | |||
Number of HLA mismatches (median (IQR)) | 4 [3–5] | 4 [3–5] | 0.003 |
Cold ischemia time (hours, median (IQR)) | 11 [7–18] | 9.5 [7–16.5] | 0.326 |
Warm ischemia time (min, median (IQR)) | 23.5 [15–36.5] | 26 [16–35] | 0.901 |
Induction treatment (Thymoglobulin, %) | 70.7 | 57 | 0.003 |
Maintenance (Tacrolimus+MPA + steroids, %) | 82.9 | 80.7 | 0.57 |
Time of follow-up (years, median [IQR]) | 1.6 [0.9–2.6] | 1.1 [0.7–1.8] | < 0.001 |