Fig. 5

Histological analysis of wild-type and male Slc3a1^−/− kidneys and bladders at 10–12 months of age. Kidneys of mice with elevated creatinine (b and d) demonstrate more tubular dilatation and fibrosis when compared to mice with a normal creatinine (a and c) whether on regular (a and b) or breeder chow (c and d). Bladders of wild-type (e), knockout with normal creatinine (f), and knockout with elevated creatinine (g) mice are also shown. The knockouts demonstrate inflammatory infiltrate and cystine crystals. Panel (g) demonstrates cystine crystals embedded within the bladder wall (arrows). Shown are representative H&E stains from each group of mice