Metabolic consequences of cystinuria

BMC Nephrology

Table 3 Plasma amino acid levels (μmole/liter)

	Female		p	Male		p	Both
	Slc3a1 ^+/+	Slc3a1 ^−/−	p	Slc3a1 ^+/+	Slc3a1 ^−/−	p	p
Aspartate	8.4 ± 1.6	8.5 ± 2.9	0.45	9.44 ± 2.94	9.6 ± 2.1	0.45
Glutamate	23 ± 2.6	35 ± 19	0.09	50 ± 10.6	46 ± 8.7	0.3
Serine/Asparagine	61 ± 9.3	46 ± 10	0.012,*	46.1 ± 5.23	51 ± 9.7	0.12
Glycine	126 ± 17	115 ± 22	0.19	104 ± 11.1	127 ± 15	0.007,*
Histidine/Glutamine	383 ± 26	363 ± 40	0.16	310 ± 44	416 ± 65	0.004,*
3-Methyhistidine	258 ± 78	275 ± 66	0.35	57 ± 9.97	46 ± 9.2	0.03,*
1-Methyhistidine	10.6 ± 1.5	11 ± 3.3	0.29	6.5 ± 0.18	5.9 ± 0.11	3.2e⁻⁵,*
Taurine	157 ± 41	101 ± 20	.007,*	108 ± 8.38	92 ± 18	0.04,*	*
Arginine	34 ± 6.9	32 ± 7.4	0.4	27 ± 4.15	30 ± 5.2	0.15
Threonine/Citruline	240 ± 25	196 ± 38	0.022,*	179 ± 38	149 ± 34	0.09
Alanine	271 ± 37	224 ± 80	0.11	248 ± 47	196 ± 40	0.03,*
Proline	76 ± 18	54 ± 15	0.027,*	57 ± 15	45 ± 14	0.1
Hydroxyproline	10 ± 2.4	6.1 ± 2	0.006,*	8.18 ± 0.88	10 ± 1.2	0.006,*
Cystine	5.9 ± 3.6	6.2 ± 3.6	0.45	13 ± 3.4	7.05 ± 1.5	0.0008,*
Tyrosine	45 ± 12	51 ± 13	0.21	37 ± 9.3	34 ± 8.7	0.28
Valine	129 ± 21	117 ± 27	0.2	110 ± 25	88 ± 24	0.07
Methionine	69 ± 15	53 ± 17	0.06	57 ± 19.3	46.5 ± 16	0.15
Ornithine	35 ± 6	11 ± 2	3.7e⁻⁶,*	34 ± 10	10.5 ± 3.2	0.0001,*	*
Lysine	200 ± 30	86 ± 15	4.5e⁻⁶,*	147 ± 31	77.4 ± 16	0.0003,*	*
Isoleucine	60 ± 11	59 ± 19	0.45	47 ± 11.6	35.3 ± 11	0.04,*
Leucine	84 ± 14	84 ± 26	0.48	69 ± 16	54.9 ± 16	0.07
Phenylalanine	36 ± 5	35 ± 5	0.32	29 ± 4	25.5 ± 4.4	0.047,*
Tryptophan	34 ± 7	26 ± 8	0.06	30 ± 3	28.1 ± 3.6	0.11

Plasma amino acid levels were determined as described in the Materials and Methods section. Rows where two amino acids are described (i.e. Histidine/Glutamine) indicates that these amino acids are not separable on the chromatogram. *, indicates a p < 0.05 via Student’s T test comparing KO to WT of that sex. The p for “both” indicates that this particular amino acids was reduced in both sexes comparing KO to WT

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