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Table 4 Cox proportional regression models on the association of albumin creatinine ratio (ACR) presented as quartiles and number of cases with dementia with its subgroups. Hazard ratios are presented with 95% confidence intervals

From: Moderately increased albuminuria, chronic kidney disease and incident dementia: the HUNT study

  

Total Dementia

NCA

Combined AD, VaD, Mixed AD/VaD

NC

AD

NC

VaD

NC

Mixed AD/VaD

NC

Other Dementia

NC

DM or HTN medicationB

ACR

 

184

 

151

 

90

 

42

 

19

 

33

Model 1C

0–.53

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

.54–.87

1.43 (.90–2.28)

 

1.64 (.96–2.80)

 

1.31 (.67–2.56)

 

2.03 (.55–7.51)

 

3.41 (.75–15.58)

 

.88 (.33–2.36)

 
 

.88–1.77

1.57 (.98–2.53)

 

1.84 (1.07–3.16)

 

1.31 (.67–2.56)

 

3.89 (1.12–13.53)

 

2.51 (.51–12.46)

 

.84 (.30–2.41)

 
 

1.78+

2.29 (1.43–3.65)

 

2.55 (1.49–4.38)

 

2.14 (1.12–4.09)

 

5.92 (1.72–20.33)

 

.55 (.05–6.12)

 

1.59 (.61–4.19)

 

Model 2D

0–.53

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

.54–.87

1.36 (.85–2.17)

 

1.56 (.91–2.66)

 

1.25 (.66–2.39)

 

1.93 (.52–7.13)

 

3.19 (.70–14.57)

 

.84 (.31–2.26)

 
 

.88–1.77

1.24 (.77–2.01)

 

1.44 (.83–2.48)

 

1.01 (.52–1.98)

 

3.24 (.93–11.34)

 

1.79 (.36–8.96)

 

.70 (.24–2.01)

 
 

1.78+

1.71 (1.06–2.75)

 

1.89 (1.10–3.26)

 

1.60 (.83–1.98)

 

4.52 (1.30–15.72)

 

.37 (.36–8.96)

 

1.24 (.46–3.31)

 

Model 3E

0–.53

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

.54–.87

1.38 (.86–2.20)

 

1.59 (.93–2.73)

 

1.28 (.67–2.46)

 

1.94 (.52–7.18)

 

3.29 (.72–15.16)

 

.82 (.30–2.21)

 
 

.88–1.77

1.22 (.75–1.98)

 

1.44 (.83–2.49)

 

1.04 (.52–2.04)

 

3.13 (.89–11.04)

 

1.69 (.33–8.54)

 

.65 (.22–1.88)

 
 

1.78+

1.66 (1.03–2.69)

 

1.87 (1.08–3.25)

 

1.61 (.83–3.13)

 

4.35 (1.24–15.28)

 

.34 (.03–3.86)

 

1.12 (.41–3.04)

 

Model 4F

0–.53

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 
 

.54–.87

1.38 (.86–2.21)

 

1.60 (.93–2.74)

 

1.30 (.68–2.50)

 

1.82 (.49–6.76)

 

3.78 (.82–17.54)

 

.83 (.31–2.24)

 
 

.88–1.77

1.23 (.76–2.00)

 

1.46 (.84–2.53)

 

1.07 (.54–2.12)

 

2.93 (.83–10.40)

 

1.87 (.37–9.53)

 

.61 (.21–1.78)

 
 

1.78+

1.65 (1.02–2.69)

 

1.85 (1.06–3.23)

 

1.66 (.85–3.24)

 

3.97 (1.12–14.07)

 

.36 (.03–4.08)

 

1.12 (.41–3.09)

 

ACR*Age

 

.11

 

.09

 

.91

 

.15

 

.24

 

.86

 

ACR*Sex

 

.46

 

.38

 

.44

 

.77

 

.20

 

.09

 
  1. A Number of dementia cases
  2. B Self-reported history of Diabetes mellitus (DM) or hypertension (HTN) medication users
  3. C Model 1: albumin creatinine ratio, quartiles (ACR)
  4. D Model 2: ACR, age, sex, education
  5. E Model 3: ACR, age, sex, education, glomerular filtration rate, cholesterol, non-fasting blood glucose, serum iron, body mass index, pulse
  6. F Model 4: ACR, age, sex, education, glomerular filtration rate, cholesterol, non-fasting blood glucose, serum iron, body mass index, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status
  7. Bold entries where adverse and inverse associations which are significant in this table