Obesity is not associated with progression to end stage renal disease in patients with biopsy-proven glomerular diseases

Table 3 Subdistribution and cause-specific hazard ratios for progression to major adverse renal event

Variable	Subdistribution hazard ratio	P	Cause-specific hazard ratio	P
Age per year increase	0.99 (0.98–1.00)	0.009	0.99 (0.98–1.00)	0.14
SBP per 10 mmHg increase	1.05 (0.98–1.11)	0.16	1.03 (0.97–1.09)	0.34
BMI (continuous– kg/m²)	0.99 (0.97–1.01)	0.31	1.01 (0.99–1.03)	0.37
BMI < 25 kg/m²	REF	–	REF	–
BMI 25–30 kg/m²	0.90 (0.65–1.24)	0.51	0.84 (0.61–1.15)	0.27
BMI > 30 kg/m²	0.83 (0.59–1.17)	0.28	0.88 (0.63–1.22)	0.44
eGFR per 10 ml/min/1.73m² increase	0.81 (0.75–0.86)	< 0.001	0.80 (0.75–0.85)	< 0.001
uPCR per 100 mg/mmol increase	1.07 (1.02–1.11)	0.002	1.06 (1.04–1.09)	< 0.001
IgAN vs MGN	1.16 (0.75–1.81)	0.50	1.30 (0.85–1.97)	0.23
FSGS vs MGN	1.19 (0.77–1.84)	0.44	1.20 (0.78–1.83)	0.40
Other vs MGN	1.35 (0.83–2.18)	0.23	1.55 (0.98–2.46)	0.06
SIMD 2 vs 1	0.86 (0.62–1.18)	0.35	0.76 (0.55–1.06)	0.11
SIMD 3 vs 1	0.81 (0.54–1.21)	0.29	0.82 (0.56–1.21)	0.32
SIMD 4 vs 1	0.96 (0.63–1.46)	0.84	0.95 (0.64–1.42)	0.80
SIMD 5 vs 1	1.06 (0.67–1.66)	0.81	1.12 (0.73–1.72)	0.60

BMI Body Mass Index, eGFR estimated glomerular filtration rate, MGN Membranous Glomerulonephritis, IgAN IgA Nephropathy, FSGS Focal Segmental Glomerulosclerosis, Other Other Primary Glomerular Diagnosis, uPCR Protein Creatinine Ratio, SIMD Scottish Index of Multiple Deprivation

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