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Table 2 Ventilator settings, arterial blood gases averaged on day 1 to 3 and other therapies

From: Clinical predictors of renal non-recovery in acute respiratory distress syndrome

Ventilator settings Recovery (96) Non-recovery (148) p value
Spontaneous tidal volume, median (IQR), mL 474 (417–539) 499 (428–555) 0.13
Tidal volume, median (IQR), (mL/kg PBW) 7.3 (6.6–8) 7.6 (6.9–8.6) 0.01*
PEEP, median (IQR), cm H2O 10 (8–13) 11 (8.4–14) 0.08
FiO2, median (IQR) 0.7 (0.53–0.82) 0.7 (0.58–0.9) 0.24
Plateau pressure, median (IQR), cm H2O 26.5 (21.3–34.4) 27.5 (23–33) 0.45
Plateau pressure > 30 cm H2O, n (%) 22 (37.9) 29 (35.4) 0.76
Driving pressure, median (IQR), cm H2O 15.0 (11.5–19) 14.5 (12–19) 0.85
Mean airway pressure, median (IQR), cm H2O 17.7 (14.5–21.8) 18 (14.8–21.2) 0.82
Peak airway pressure, mean (SD), cm H2O 31 (6.9) 31.3 (7.6) 0.82
Minute ventilation, median (IQR), L/min 11 (9.2–12.9) 11.6 (9.9–13.5) 0.20
Arterial blood gas
 Arterial pH, median (IQR) 7.36 (7.3–7.41) 7.35 (7.29–7.39) 0.06
 PaCO2, median (IQR), mm Hg 43.7 (38–51.2) 41.3 (34.8–48) 0.07
 PaO2, median (IQR), mm Hg 87.7 (74.8–112) 87.3 (76–109.2) 0.93
 PaO2:FiO2, median (IQR) 138 (111–178) 138 (95–195) 0.94
 Oxygenation index, median (IQR) 15.6 (9.2–23.5) 13.9 (9.1–24.4) 0.89
Rescue therapies, n (%)
 Continuous neuromuscular blocking agents 27 (28.1) 72 (48.6) 0.001*
 Inhaled vasodilators 18 (18.8) 46 (31.1) 0.03*
 Prone positioning 14 (14.6) 20 (13.5) 0.81
 Extracorporeal membrane oxygenation 3 (3.1) 4 (2.7) 1.00
 Recruitment maneuvers 3 (3.1) 17 (11.5) 0.02*
 High frequency oscillatory ventilation 2 (2.1) 9 (6.1) 0.21
Other therapies
 Sedative drugs, n (%) 77 (80.2) 117 (79.1) 0.83
 Analgesic drugs, n (%) 70 (72.9) 106 (71.6) 0.83
 Antipsychotic drugs, n (%) 48 (50) 56 (37.8) 0.06
 Furosemide on day 2–7, n (%) 63 (65.6) 71 (48) 0.01*
 Fluid overload on day 7, mean (SD), % 5.5 (8.2) 10 (8.7) 0.003*
  1. FiO2 = fraction of inspired oxygen, IQR = interquartile range, PaCO2 = partial pressure of carbon dioxide in arterial blood, PaO2 = partial pressure of oxygen in arterial blood, PBW = predicted body weight, PEEP = positive end-expiratory pressure, SD = standard deviation
  2. *p < 0.05 when compared with patients complete renal recovery