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Table 1 Patient characteristics and comparison between patients with above- and below-median sclerostin levels

From: Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study

Characteristics

Total

Sclerostin

≥ 80.2 pmol/L

Sclerostin

< 80.2 pmol/L

P value

Number of patients

89

45

44

 

Age (year)

49.2 ± 10.6

51.4 ± 10.3

47.0 ± 10.6

0.048

Sex-male

44 (49.4)

28 (62.2)

16 (36.4)

0.015

Dialysis vintage (day)

1490 (649–2392)

1401 (742–2385)

1777 (552–2431)

0.752

Weight (kg)

62.5 ± 13.0

65.7 ± 12.3

59.2 ± 13.0

0.016

Height (cm)

162.4 ± 8.1

164.1 ± 7.4

160.7 ± 8.6

0.048

BMI (kg/m2)

23.6 ± 3.8

24.3 ± 3.7

22.8 ± 3.8

0.051

Total Kt/V for urea

1.95 (1.84–2.09)

1.94 (1.82–2.08)

1.97 (1.86–2.10)

0.036

Baseline comorbidities

 Diabetes mellitus

13 (14.6)

10 (22.2)

3 (6.8)

0.040

 Hypertension

62 (69.7)

33 (73.3)

29 (65.9)

0.446

 Parathyroidectomy

17 (19.1)

10 (22.2)

7 (15.9)

0.449

 Anuria

46 (51.7)

24 (53.3)

22 (50.0)

0.753

Serum biochemistry

 Sclerostin (pmol/L)

80.2 (60.2–107)

107.0 (87.0–135)

69.1 (50.6–69.1)

< 0.001

 FGF-23 (pg/mL)

3193 (1878–3547)

3193 (2003–3442)

3173(1863–3559)

0.902

 DKK-1 (pg/mL)

981 ± 356

1048 ± 402

912 ± 290

0.071

 CTX (ng/mL)

2.70 (2.14–3.38)

2.68 (2.19–3.25)

2.91 (2.08–3.66)

0.408

 25(OH)-Vitamin D (ng/mL)

22.7 ± 7.5

24.2 ± 7.3

21.3 ± 7.4

0.067

 Osteocalcin (ng/mL)

177 (98.3–349)

137 (97.3–264)

228 (106–563)

0.025

 Intact PTH (pg/mL)

315 (119–564)

199 (111–458)

399 (169–718)

0.008

 Urea nitrogen (mg/dL)

64.7 ± 17.2

65.9 ± 16.4

63.5 ± 18.1

0.520

 Creatinine (mg/dL)

12.6 ± 2.9

13.3 ± 2.6

12.0 ± 3.0

0.038

 Calcium (mg/dL)

9.6 ± 0.7

9.5 ± 0.7

9.7 ± 0.7

0.345

 Phosphorus (mg/dL)

5.1 (4.3–6.0)

5.1 (4.3–6.0)

5.1 (4.2–6.2)

0.735

 Magnesium (mg/dL)

2.1 ± 0.4

2.1 ± 0.4

2.1 ± 0.4

0.994

 Albumin (g/dL)

3.9 (3.7–4.1)

3.9 (3.7–4.2)

3.9 (3.7–4.1)

0.999

 Alkaline phosphatase (U/L)

104 (70–143)

92 (68–120)

115 (71–159.5)

0.191

 Cholesterol (mg/dL)

186.0 ± 44.6

183.4 ± 41.4

188.7 ± 48.0

0.581

 Triglyceride (mg/dL)

141 (104–254)

155 (88–257)

132 (104–224)

0.620

 Hemoglobin (g/dL)

10.5 (9.6–11.4)

10.8 (9.8–11.6)

10.4 (9.4–10.9)

0.062

 Glucose (mg/dL)

96 (91–113)

101 (92–122)

93 (89–99.5)

0.012

 Uric acid (mg/dL)

6.8 ± 1.4

7.1 ± 1.4

6.4 ± 1.3

0.021

 hsCRP (mg/L)

2.36 (0.81–8.97)

3.53 (0.89–8.97)

2.14 (0.54–7.91)

0.548

BMD, spine L1 to L4 (g/cm2)

1.16 ± 0.18

1.22 ± 0.17

1.10 ± 0.18

0.001

BMD spine T-score

0.12 ± 1.50

0.56 ± 1.40

−0.33 ± 1.47

0.004

BMD spine Z-score

0.32 ± 1.32

0.74 ± 1.31

− 0.12 ± 1.19

0.002

Ankle brachial index

1.10 ± 0.09

1.09 ± 0.10

1.11 ± 0.08

0.352

Pulse wave velocity (m/s)

15.0 ± 2.5

15.1 ± 2.7

14.9 ± 2.2

0.783

  1. BMI body mass index, FGF-23 fibroblast growth factor 23, DKK-1 dickkopf-1, CTX cross-linked C-telopeptide of type 1 collagen, PTH parathyroid hormone, hsCRP high-sensitivity C-reactive protein, BMD bone mineral density