Characteristics | Total | Sclerostin ≥ 80.2 pmol/L | Sclerostin < 80.2 pmol/L | P value |
---|---|---|---|---|
Number of patients | 89 | 45 | 44 | |
Age (year) | 49.2 ± 10.6 | 51.4 ± 10.3 | 47.0 ± 10.6 | 0.048 |
Sex-male | 44 (49.4) | 28 (62.2) | 16 (36.4) | 0.015 |
Dialysis vintage (day) | 1490 (649–2392) | 1401 (742–2385) | 1777 (552–2431) | 0.752 |
Weight (kg) | 62.5 ± 13.0 | 65.7 ± 12.3 | 59.2 ± 13.0 | 0.016 |
Height (cm) | 162.4 ± 8.1 | 164.1 ± 7.4 | 160.7 ± 8.6 | 0.048 |
BMI (kg/m2) | 23.6 ± 3.8 | 24.3 ± 3.7 | 22.8 ± 3.8 | 0.051 |
Total Kt/V for urea | 1.95 (1.84–2.09) | 1.94 (1.82–2.08) | 1.97 (1.86–2.10) | 0.036 |
Baseline comorbidities | ||||
Diabetes mellitus | 13 (14.6) | 10 (22.2) | 3 (6.8) | 0.040 |
Hypertension | 62 (69.7) | 33 (73.3) | 29 (65.9) | 0.446 |
Parathyroidectomy | 17 (19.1) | 10 (22.2) | 7 (15.9) | 0.449 |
Anuria | 46 (51.7) | 24 (53.3) | 22 (50.0) | 0.753 |
Serum biochemistry | ||||
Sclerostin (pmol/L) | 80.2 (60.2–107) | 107.0 (87.0–135) | 69.1 (50.6–69.1) | < 0.001 |
FGF-23 (pg/mL) | 3193 (1878–3547) | 3193 (2003–3442) | 3173(1863–3559) | 0.902 |
DKK-1 (pg/mL) | 981 ± 356 | 1048 ± 402 | 912 ± 290 | 0.071 |
CTX (ng/mL) | 2.70 (2.14–3.38) | 2.68 (2.19–3.25) | 2.91 (2.08–3.66) | 0.408 |
25(OH)-Vitamin D (ng/mL) | 22.7 ± 7.5 | 24.2 ± 7.3 | 21.3 ± 7.4 | 0.067 |
Osteocalcin (ng/mL) | 177 (98.3–349) | 137 (97.3–264) | 228 (106–563) | 0.025 |
Intact PTH (pg/mL) | 315 (119–564) | 199 (111–458) | 399 (169–718) | 0.008 |
Urea nitrogen (mg/dL) | 64.7 ± 17.2 | 65.9 ± 16.4 | 63.5 ± 18.1 | 0.520 |
Creatinine (mg/dL) | 12.6 ± 2.9 | 13.3 ± 2.6 | 12.0 ± 3.0 | 0.038 |
Calcium (mg/dL) | 9.6 ± 0.7 | 9.5 ± 0.7 | 9.7 ± 0.7 | 0.345 |
Phosphorus (mg/dL) | 5.1 (4.3–6.0) | 5.1 (4.3–6.0) | 5.1 (4.2–6.2) | 0.735 |
Magnesium (mg/dL) | 2.1 ± 0.4 | 2.1 ± 0.4 | 2.1 ± 0.4 | 0.994 |
Albumin (g/dL) | 3.9 (3.7–4.1) | 3.9 (3.7–4.2) | 3.9 (3.7–4.1) | 0.999 |
Alkaline phosphatase (U/L) | 104 (70–143) | 92 (68–120) | 115 (71–159.5) | 0.191 |
Cholesterol (mg/dL) | 186.0 ± 44.6 | 183.4 ± 41.4 | 188.7 ± 48.0 | 0.581 |
Triglyceride (mg/dL) | 141 (104–254) | 155 (88–257) | 132 (104–224) | 0.620 |
Hemoglobin (g/dL) | 10.5 (9.6–11.4) | 10.8 (9.8–11.6) | 10.4 (9.4–10.9) | 0.062 |
Glucose (mg/dL) | 96 (91–113) | 101 (92–122) | 93 (89–99.5) | 0.012 |
Uric acid (mg/dL) | 6.8 ± 1.4 | 7.1 ± 1.4 | 6.4 ± 1.3 | 0.021 |
hsCRP (mg/L) | 2.36 (0.81–8.97) | 3.53 (0.89–8.97) | 2.14 (0.54–7.91) | 0.548 |
BMD, spine L1 to L4 (g/cm2) | 1.16 ± 0.18 | 1.22 ± 0.17 | 1.10 ± 0.18 | 0.001 |
BMD spine T-score | 0.12 ± 1.50 | 0.56 ± 1.40 | −0.33 ± 1.47 | 0.004 |
BMD spine Z-score | 0.32 ± 1.32 | 0.74 ± 1.31 | − 0.12 ± 1.19 | 0.002 |
Ankle brachial index | 1.10 ± 0.09 | 1.09 ± 0.10 | 1.11 ± 0.08 | 0.352 |
Pulse wave velocity (m/s) | 15.0 ± 2.5 | 15.1 ± 2.7 | 14.9 ± 2.2 | 0.783 |