Serum sclerostin levels are positively related to bone mineral density in peritoneal dialysis patients: a cross-sectional study

Table 3 Logistic regression analysis of association of above-median sclerostin levels with clinical and biochemical parameters

Variable	Univariate analysis	P value	Multivariate analysis
	Univariate analysis		Model 1^a	P value	Model 2^b	P value
	Odds ratio (95% CI)		Odds ratio (95% CI)	P value	Odds ratio (95% CI)	P value
Age (year)	1.042 (1.000–1.087)	0.052
Sex-male	2.882 (1.219–6.815)	0.016
Weight (Kg)	1.041 (1.003–1.081)	0.035	1.030 (0.988–1.074)	0.167
Total Kt/V for urea	0.311 (0.045–2.145)	0.236	0.560 (0.071–4.447)	0.584	0.414 (0.041–4.190)	0.455
Diabetes mellitus	3.905 (0.995–15.317)	0.051	3.757 (0.932–15.141)	0.063	3.183 (0.685–14.791)	0.140
Osteocalcin (ng/mL)	0.998 (0.997–1.000)	0.034	0.998 (0.997–1.000)	0.027	0.998 (0.996–1.000)	0.016
Intact PTH (pg/mL)	0.998 (0.997–1.000)	0.015	0.998 (0.996–0.999)	0.009	0.998 (0.996–0.999)	0.006
Uric acid (mg/dL)	1.454 (1.049–2.016)	0.025	1.511 (1.068–2.137)	0.020	1.481 (1.030–2.129)	0.034
BMD, spine L1 to L4 (g/cm²)	65.61 (4.414–975)	0.002	172.0 (6.675–4431)	0.002	121.5 (3.634–4061)	0.007
BMD spine T-score	1.546 (1.129–2.117)	0.007	1.862 (1.261–2.749)	0.002	1.792 (1.173–2.737)	0.007
BMD spine Z-score	1.783 (1.209–2.630)	0.001	1.838 (1.203–2.806)	0.005	1.765 (1.143–2.724)	0.010

CI confidence interval, PTH parathyroid hormone, BMD bone mineral density
^amodel 1: adjusted for age and gender; ^bmodel 2: adjusted for age, gender, and weight

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