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Table 2 AUC of biomarkers to predict AKI after cardiac surgery

From: Urine klotho is a potential early biomarker for acute kidney injury and associated with poor renal outcome after cardiac surgery

 

AUC (95% CI)

Cut-off (Sensitivity, Specificity)

p value

Urine Klotho (ng/umol)

 The first postoperative

0.86*** (0.78, 0.94)

0.86 (93.9, 75.9%)

< 0.001

 2 h admission to the ICU

0.85 (0.76, 0.94)

0.82 (87.5, 77.6%)

< 0.001

 4 h admission to the ICU

0.78*** (0.76, 0.94)

0.70 (90.6, 62.1%)

< 0.001

Urine NGAL (ng/umol)

 The first postoperative

0.59 (0.46, 0.71)

4.39 (72.7, 56.6%)

0.177

 2 h admission to the ICU

0.78 (0.68, 0.88)

4.49 (87.9, 71.7%)

< 0.001

4 h admission to the ICU

0.57 (0.44, 0.70)

4.64 (57.6, 64.2%)

0.285

  1. AUC Area under the ROC, NGAL Neutrophil gelatinase-associated lipocalin
  2. ***P < 0.001 compared with the AUCs of urine NGAL at indicated time points