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Table 1 Baseline characteristics of study population

From: A single-arm pilot study of metformin in patients with autosomal dominant polycystic kidney disease

Variables Patients number (N = 34)
Age (mean, years) 47.29 ± 11.29
Gender (%)
 Male 12 (35.3%)
 Female 22 (64.7%)
Family history of ADPKD (%) 28 (82.4%)
 Mother related 11 (32.4%)
 Father related 17 (50%)
 None 6 (17.6%)
Age at diagnosis (mean, years) 35.97 ± 11.66
BMI (mean, kg/m2) 27.10 ± 3.65
 25–29.9 (%) 17 (50%)
  ≥ 30 (%) 8 (23.5%)
Smoking status (%)
 Current smoker 10 (29.4%)
 Past smoker 6 (17.6%)
 Non-smoker 18 (52.9%)
History of hematuria (%) 4 (11.8%)
History of kidney stones (%) 12 (35.3%)
History of lumbar pain (%) 28 (82.4%)
History of UTI (%) 14 (44.1%)
HTN (%) 26 (76.5%)
Dyslipidemia (%) 23 (67.6%)
SBP (mean, mmHg) 136.18 ± 15.42
DBP (mean, mmHg) 83.09 ± 11.54
Serum creatinine (median, mg/dl) 1.11 (0.88–2.61)
eGFR (mean, ml/min/1.73m2) 60.45 ± 34.71
CKD stage (%)
 1 8 (23.5%)
 2 10 (29.4%)
 3 5 (14.7%)
 4 6 (17.6%)
 5 5 (14.7%)
Serum urea (median, mg/dl) 59 (36.42–80.75)
Glucose level (mean, mg/dl) 87.75 ± 15.90
Total cholesterol (mean, mg/dl) 186.88 ± 37.32
Triglycerides (median, mg/dl) 95.50 (70–145.25)
Antihypertensive treatment (%) 21 (61.8%)
ACEI/ARB (%) 18 (52.9%)
Urine specific gravity (mean) 1012 ± 6.39
  1. N number, ADPKD autosomal dominant polycystic kidney disease, BMI body mass index, UTI urinary tract infections, HTN arterial hypertension, SBP systolic blood pressure, DBP diastolic blood pressure, GFR glomerular filtration rate, CKD chronic kidney disease, ACEI angiotensin converting enzyme inhibitors, ARB angiotensin II receptor blockers
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