Fig. 1

The candidate SNPs screening process by biometrics for this study. First, we used a total of 58,917,994 SNPs (997 samples) in the Taiwan Biobank database to screen for a Taiwanese-specific genetic variation. Then, through genetic alignment of GRCh37/hg19 from the NCBI, we found that NF-κB (p50–p65) contained 271,063 potentials in the human genome based on the sequence of the above binding sites. Of the TFBSs, we compared the remaining 36,041,790 SNPs in the first step and found that there were 3,121,467 SNPs around the 271,063 potential TFBSs, of which 40,137 SNPs were even on the TFBS of NF-κB. Finally, we validated these with the results of the second stage through the ChIP-Seq database to further confirm that these mutations do have a combination of these positions. The 15 SNPs variation may affect NF-κB binding activity