Table 3 Genotype distribution of NF-κB binding site SNPs with ESRD cases and control group
SNPs | Control (N = 847) | ESRD (N = 847) | Crude-OR (95% CI) | p-value | Adj-OR (95% CI) a | p-value |
|---|---|---|---|---|---|---|
rs11826681C/G | 0.385 | 0.251 | ||||
CC | 304 (35.9%) | 288 (34.3%) | 1.00 | 1.00 | ||
CG | 421 (49.7%) | 418 (48.9%) | 1.03 (0.83–1.27) | 0.798 | 1.00 (0.81–1.25) | 0.970 |
GG | 122 (14.4%) | 141 (16.8%) | 1.22 (0.91–1.63) | 0.181 | 1.26 (0.94–1.70) | 0.128 |
rs17036427G/C | 0.825 | 0.826 | ||||
GG | 723 (85.4%) | 718 (84.8%) | 1.00 | 1.00 | ||
GC | 119 (14.0%) | 122 (14.4%) | 1.03 (0.79–1.36) | 0.819 | 1.00 (0.75–1.32) | 0.990 |
CC | 5 (0.6%) | 7 (0.8%) | 1.41 (0.45–4.46) | 0.559 | 1.44 (0.45–4.63) | |
rs59118205C/T | 0.624 | 0.905 | ||||
CC | 745 (88.0%) | 753 (89.0%) | 1.00 | 1.00 | ||
TC | 98 (11.6%) | 92 (10.8%) | 0.92 (0.68–1.24) | 0.583 | 0.93 (0.68–1.27) | 0.935 |
TT | 4 (0.5%) | 2 (0.2%) | 0.49 (0.09–2.71) | 0.417 | 1.09 (0.15–7.87) | 0.662 |
rs7284245G/T | 0.234 | 0.220 | ||||
GG | 611 (72.3%) | 582 (69.5%) | 1.00 | 1.00 | ||
GT | 211 (25.0%) | 247 (28.4%) | 1.18 (0.95–1.47) | 0.127 | 1.15 (0.92–1.44) | 0.210 |
TT | 23 (2.7%) | 18 (2.1%) | 0.82 (0.44–1.54) | 0.539 | 0.70 (0.36–1.34) | 0.278 |
rs7651075G/A | 0.104 | 0.139 | ||||
GG | 219 (25.9%) | 185 (22.0%) | 1.00 | 1.00 | ||
AG | 398 (46.9%) | 440 (51.5%) | 1.29 (1.02–1.64) | 0.036 | 1.26 (0.99–1.61) | 0.062 |
AA | 230 (27.2%) | 222 (26.4%) | 1.14 (0.87–1.50) | 0.331 | 0.12 (0.85–1.48) | 0.417 |
rs77836284C/T | 0.775 | 0.662 | ||||
CC | 703 (83.8%) | 709 (84.4%) | 1.00 | 1.00 | ||
TC | 133 (14.9%) | 130 (14.6%) | 0.98 (0.74–1.28) | 0.858 | 1.03 (0.78–1.36) | 0.856 |
TT | 11 (1.3%) | 8 (1.0%) | 0.72 (0.29–1.80) | 0.484 | 0.65 (0.25–1.70) | 0.378 |
rs78229468A/G | 0.518 | 0.719 | ||||
AA | 697 (82.4%) | 696 (82.3%) | 1.00 | 1.00 | ||
GA | 146 (17.1%) | 143 (16.8%) | 0.98 (0.76–1.26) | 0.881 | 0.98 (0.75–1.27) | 0.859 |
GG | 4 (0.5%) | 8 (0.9%) | 2.00 (0.60–6.68) | 0.258 | 1.65 (0.47–5.74) | 0.432 |
rs79143300G/T | 0.668 | 0.464 | ||||
GG | 737 (87.0%) | 731 (86.3%) | 1.00 | 1.00 | ||
GT | 105 (12.4%) | 113 (13.3%) | 1.09 (0.82–1.44) | 0.574 | 1.11 (0.83–1.49) | 0.471 |
TT | 5 (0.6%) | 3 (0.4%) | 0.60 (0.14–2.54) | 0.492 | 0.43 (0.08–2.26) | 0.321 |
rs9395890G/T | 0.031* | 0.049* | ||||
GG | 153 (18.1%) | 138 (16.4%) | 1.00 | 1.00 | ||
GT | 419 (49.5%) | 379 (45.1%) | 1.00 (0.77 to 1.31) | 0.983 | 0.98 (0.75 to 1.29) | 0.110 |
TT | 274 (32.4%) | 324 (38.5%) | 1.31 (0.99 to 1.74) | 0.059 | 1.26 (0.95 to 1.68) | 0.908 |
rs9925427A/G | 0.902 | 0.826 | ||||
AA | 638 (77.2%) | 665 (79.1%) | 1.00 | 1.00 | ||
GA | 208 (22.7%) | 192 (20.9%) | 0.95 (0.75–1.20) | 0.650 | 0.93 (0.73–1.18) | 0.537 |
GG | 1 | 0 | 0.00 (0.00 - inf) | 0.969 | 0.00 (0.00-inf) | 0.969 |