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Table 1 Baseline characteristics

From: Comparison of the effects of hydroxychloroquine and corticosteroid treatment on proteinuria in IgA nephropathy: a case-control study

 

HCQ group (n = 92)

Corticosteroid group (n = 92)

p value

Age (years)

37.0 ± 10.0

37.2 ± 12.6

0.91

Sex (male/female)

46/46

46/46

1.00

MAP (mmHg)

90.6 ± 9.3

90.5 ± 9.2

0.96

Scr (μmol/L)

119.8 ± 37.7

127.6 ± 53.8

0.26

Baseline eGFR (ml/min/1.73 m2)

56.8 ± 20.4

55.2 ± 22.9

0.61

Baseline UTP (g/d)

1.7 (1.2, 2.3)

1.8 (1.3, 2.5)

0.96

Oxford classification*

 M 0/1

40/48

50/38

0.13

 E 0/1

58/30

48/40

0.12

 S 0/1

24/64

27/61

0.62

 T 0/1/2

55/26/7

51/23/14

0.26

 C 0/1/2

28/50/10

22/55/11

0.61

RAASi therapy (% of patients)

98.9

100

0.27

 ACEI alone

38.0

48.9

 

 ARB alone

46.7

42.4

 

 ACEI plus ARB

14.1

8.7

 

Immunosuppressive therapy (% of patients)

0

42.4

 

 Cyclophosphamide

 

32.6

 

 Mycophenolate mofetil

 

5.4

 

 Calcineurin inhibitors

 

2.2

 

 Leflunomide

 

1.1

 

 Tripterygium glycosides

 

1.1

 

Aldosterone antagonist therapy (% of patients)

10.9

2.2

0.02

Traditional Chinese medicine (% of patients)

2.2

5.4

0.44

  1. Abbreviations: MAP mean arterial pressure, SCr serum creatinine, eGFR estimated glomerular filtration rate (calculated using the CKD-EPI equation); RAASi renin-angiotensin-aldosterone system inhibitor, ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin receptor blocker
  2. *4 histological scores unavailable in the HCQ group because 2 patients received renal biopsy in other clinics, and the glomeruli were less than 8 on the renal specimen of the other 2 patients. 4 histological scores unavailable in the Corticosteroid group because 1 patient received renal biopsy in other clinic, 1 specimen was of poor quality that can’t be graded, and the glomeruli were less than 8 on the renal specimen of the other 2 patients