Table 2 Predictive values of urine and serum/plasma NGAL for DGF in individual studies
Study (y) | Sampling Time (h) | AUC (95% CI) | Sensitivity (%) | Specificity (%) | Cut-off (ng/ml) | TP | FP | FN | TN | Sample size |
|---|---|---|---|---|---|---|---|---|---|---|
Urine NGAL | ||||||||||
Parikh (2006) [8] | 24 | 0.90 (0.71–1.00) | 90.0 | 83.0 | 1000# | 9 | 3 | 1 | 17 | 30 |
Hall (2010) [9] | 24 | 0.82 (0.72–0.92) | 65.0 | 94.0 | 800 | 26 | 15 | 8 | 42 | 91 |
Hollmen (2011) [11] | 24 | 0.74 (0.64–0.83) | 65.0 | 74.0 | 560 | 43 | 29 | 23 | 81 | 176 |
Kanter (2013) [21] | 24 | 0.71 (0.51–0.91) | 85.7 | 61.5 | 128 | 13 | 9 | 2 | 14 | 38 |
Fonseca (2013) [14] | 24 | 0.88 (0.77–1.00) | 100.0 | 76.0 | 286 | 18 | 5 | 0 | 17 | 40 |
48 | 0.96 (0.90–1.00) | 93.0 | 90.0 | 277 | 17 | 2 | 1 | 20 | 40 | |
Cui (2015) [17] | 24 | 0.834 (0.677–0.992) | 70.0 | 93.7 | 688.3 | 15 | 6 | 6 | 96 | 123 |
48 | 0.897 (0.764–0.969) | 80.0 | 96.9 | 295.2 | 17 | 3 | 4 | 99 | 123 | |
Lacquaniti (2016) [18] | 24 | 0.97 (0.90–0.99) | 95.8 | 91.9 | 105 | 21 | 1 | 1 | 6 | 29 |
Nieto-Rios (2016) [19] | 48 | 0.80 (NR) | 75.0 | 70.0 | 120 | 10 | 20 | 3 | 46 | 79 |
Serum or plasma NGAL | ||||||||||
Bataille (2011) [10] | 24 h | 0.97 (0.93–1.00) | 93.3 | 88.5 | 400 | 14 | 3 | 1 | 23 | 41 |
Lee (2012) [13] | 24 h | 0.86 (0.75–0.98) | 78.6 | 77.8 | 233.3 | 11 | 10 | 3 | 35 | 59 |
Kusaka (2012) [12] | 24 h | 0.99 (NR) | 91.0 | 97.0 | 500 | 12 | 2 | 1 | 52 | 67 |
Hollmen (2014) [15] | 24 h | 0.85 (0.79–0.91) | 87.0 | 77.0 | 423 | 57 | 25 | 9 | 85 | 176 |
Cantaluppi (2015) [16] | 24 h | 0.94 (NR) | 90.9 | 80.6 | 532 | 13 | 7 | 1 | 29 | 50 |
Pezeshgi (2016) [20] | 24 h | 0.97 (NR) | 100 | 92 | 317 | 12 | 2 | 0 | 23 | 37 |