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Table 2 Univariate and multivariate Fine and Gray competing risk regression analyses

From: Use of estimated glomerular filtration rate to predict incident chronic kidney disease in patients at risk of cardiovascular disease: a retrospective study

Characteristics

Univariate analyses

Multivariate analyses (Full model)a

Multivariate analyses (Stepwise model)b

SHR (95% CI)

Coefficient

P value

SHR (95% CI)

Coefficient

P value

SHR (95% CI)

Coefficient

P value

Age (years)

1.06 (1.05–1.08)

0.06

< 0.001

1.01 (0.98–1.03)

0.01

0.680

–

–

–

Sex

 Female

Ref.

Ref.

–

Ref.

Ref.

–

–

–

–

 Male

1.48 (0.93–2.36)

0.39

0.099

0.73 (0.39–1.36)

−0.32

0.320

–

–

–

CVD

 No

Ref.

Ref.

–

Ref.

Ref.

–

–

–

–

 Yes

3.91 (2.38–6.40)

1.36

< 0.001

0.74 (0.40–1.38)

−0.30

0.340

–

–

–

Smoking

 No

Ref.

Ref.

–

Ref.

Ref.

–

–

–

–

 Yes

1.74 (0.99–3.07)

0.55

0.056

1.84 (0.95–3.57)

0.61

0.072

–

–

–

DM

 No

Ref.

Ref.

–

Ref.

Ref.

–

Ref.

Ref.

–

 Yes

5.00 (3.05–8.20)

1.61

< 0.001

2.01 (1.03–3.91)

0.70

0.040

2.17 (1.12–4.21)

0.78

0.022

HTN

 No

Ref.

Ref.

–

Ref.

Ref.

–

–

–

–

 Yes

3.58 (1.89–6.81)

1.28

< 0.001

1.20 (0.57–2.53)

0.18

0.640

–

–

–

Dyslipidemia

 No

Ref.

Ref.

–

Ref.

Ref.

–

–

–

–

 Yes

2.90 (1.68–4.99)

1.06

< 0.001

1.05 (0.54–2.07)

0.05

0.880

–

–

–

BMI (kg/m2)

1.00 (0.96–1.03)

−0.004

0.820

Not applicablec

–

–

Not applicablec

–

–

SBP (mmHg)

1.02 (1.01–1.04)

0.02

0.006

1.02 (1.00–1.04)

0.02

0.096

–

–

–

DBP (mmHg)

0.98 (0.96–1.00)

−0.02

0.069

0.98 (0.96–1.01)

−0.02

0.200

–

–

–

TC (mmol/L)

0.74 (0.59–0.93)

−0.30

0.009

0.73 (0.59–0.91)

−0.31

0.005

0.82 (0.69–0.96)

−0.20

0.015

TG (mmol/L)

1.14 (1.00–1.29)

0.13

0.051

1.15 (0.92–1.45)

0.14

0.230

–

–

–

eGFR (mL/min/1.73 m2)

0.92 (0.90–0.93)

−0.09

< 0.001

0.92 (0.90–0.94)

−0.09

< 0.001

0.92 (0.91–0.94)

−0.08

< 0.001

HbA1c (%)

1.38 (1.29–1.48)

0.32

< 0.001

1.18 (1.02–1.36)

0.16

0.027

1.22 (1.08–1.38)

0.20

0.002

  1. CVD cardiovascular disease, DM diabetes mellitus, HTN hypertension, BMI body mass index, eGFR estimated glomerular filtration rate, SBP systolic blood pressure, DBP diastolic blood pressure, SCr serum creatinine, TC total cholesterol, TG triglycerides, HbA1c glycosylated hemoglobin A1C, SHR sub-distribution hazard ratio, CI confidence interval
  2. aSub-distribution hazards model, adjusted for all predictors in the final model with all variables included
  3. bSub-distribution hazards model, adjusted for all predictors in the final model selected using backward-stepwise selection
  4. cP value > 0.2 in the initial univariate analyses and not included in the multivariate analyses
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BMC Nephrology

ISSN: 1471-2369

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