Focal segmental glomerulosclerosis, excluding atypical lesion, is a predictor of renal outcome in patients with membranous nephropathy: a retrospective analysis of 716 cases

Table 2 Univariate analysis of risk factors for progression to primary outcome– Cox proportional hazards model

Parameters	P value	HR	HR(95% CI)
Male	0.199	1.505	0.806–2.807
Age ≥ 60 years	< 0.001	4.430	2.406–8.157
Hypertension	< 0.001	4.591	2.134–9.878
Albumin(g/L)
≥ 30			1.00 (referent)
20–29.9	0.965	1.020	0.414–2.517
≤ 19.9	0.289	1.674	0.646–4.339
Urine protein content(g/24 h)
< 3.9			1.00 (referent)
4–7.9	0.962	1.017	0.511–2.023
≥ 8	0.258	1.549	0.725–3.311
Serum creatinine≥134(umol/L)	< 0.001	16.888	8.164–34.932
eGFR< 60(ml/min per 1.73 m²)	< 0.001	9.509	5.178–17.460
FSL (FSGS,aFSL = 1,FSL⁻ = 0)	< 0.001	3.822	1.961–7.447
FSL
FSL⁻			1.00 (referent)
FSGS	< 0.001	6.902	3.493–13.635
aFSL	0.914	0.939	0.302–2.919
Stage
I			1.00 (referent)
II	0.31	1.455	0.706–2.998
III and IV	0.237	1.705	0.704–4.133
Global glomerulosclerosis (> 5%)	< 0.001	5.212	2.680–10.136
Proliferation of mesangial area
0			1.00 (referent)
1	0.034	2.095	1.059–4.147
2 and 3	0.061	2.741	0.956–7.858
Tubulointerstitial fibrosis (area ≥ 15%)	< 0.001	7.368	4.050–13.404
Vascular sclerosis
0			1.00 (referent)
1	0.036	4.725	1.104–20.223
2	0.002	10.617	2.440–46.203
3	< 0.001	30.771	6.141–154.175

Abbreviations: HR Hazard ratio, CI Confidence interval; Datas are presented as n (%), or median (interquartile range)

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