Admission serum sodium and potassium levels predict survival among critically ill patients with acute kidney injury: a cohort study

Table 1 Relationship between admission serum sodium level and mortality among critically ill patients with acute kidney injury

Serum sodium level, mmol/L	No. of patients/deaths	Model 1 ^a		Model 2 ^b
Serum sodium level, mmol/L	No. of patients/deaths	HR (95% CIs)	P value	HR (95% CIs)	P value
90-Day all-cause mortality
Fitted groups
< 136.0	3678/1066	1.68 (1.55, 1.81)	< 0.001	1.38 (1.27, 1.50)	< 0.001
136.0–144.9	9161/1827	1.00		1.00
≥ 145.0	782/261	1.76 (1.54, 2.01)	< 0.001	1.56 (1.36, 1.79)	< 0.001
Quintiles
< 135.0	2910/880	2.00 (1.81, 2.20)	< 0.001	1.57 (1.41, 1.75)	< 0.001
135.0–138.9	4193/902	1.22 (1.10, 1.35)	< 0.001	1.16 (1.04, 1.28)	0.005
139.0–141.9	3914/722	1.00		1.00
142.0–145.9	2063/459	1.25 (1.11, 1.40)	< 0.001	1.24 (1.10, 1.40)	< 0.001
≥ 146.0	541/191	2.05 (1.74, 2.41)	< 0.001	1.75 (1.48, 2.07)	< 0.001
30-Day all-cause mortality
Fitted groups
< 136.0	3678/747	1.70 (1.55, 1.86)	< 0.001	1.37 (1.24, 1.51)	< 0.001
136.0–144.9	9161/1226	1.00		1.00
≥ 145.0	782/184	1.79 (1.53, 2.10)	< 0.001	1.51 (1.28, 1.78)	< 0.001
Quintiles
< 135.0	2910/618	2.03 (1.80, 2.29)	< 0.001	1.55 (1.36, 1.77)	< 0.001
135.0–138.9	4193/623	1.25 (1.11, 1.41)	< 0.001	1.18 (1.05, 1.34)	0.008
139.0–141.9	3914/479	1.00		1.00
142.0–145.9	2063/300	1.22 (1.05, 1.41)	0.008	1.20 (1.03, 1.39)	0.018
≥ 146.0	541/137	2.12 (1.75, 2.58)	< 0.001	1.68 (1.37, 2.05)	< 0.001

Abbreviations: CI confidence interval, HR hazard ratio
^a Models were derived from Cox proportional hazards regression models. Model 1 covariates were adjusted for age, and sex
^b Model 2 covariates were also adjusted for blood urea nitrogen, creatinine, urine output, Glasgow Coma Scale score, non-renal Sepsis Related Organ Failure Assessment score, vasopressin use, ventilator use, cardiovascular diseases, chronic pulmonary disease, deficiency anemias, liver disease, tumor related diseases

ISSN: 1471-2369