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Fig. 1 | BMC Nephrology

Fig. 1

From: A novel single amino acid deletion impairs fibronectin function and causes familial glomerulopathy with fibronectin deposits: case report of a family

Fig. 1

Renal histological and ultrastructural findings in the child (a, c, e, g, i, k, m and o) and his father (b, d, f, h, j, l, n, p), affected by Glomerulopathy with Fibronectin Deposits. a and b - Glomeruli with increased size, lobed, with endocapillary hypercellularity mainly due to mesangial cells. Eosinophilic, homogeneous coarse deposits in mesangial and subendothelial regions (HE, 20x obj.). c and d - The referred deposits are negative to Sirius red staining (SR, 20x obj.). e and f - Deposits are also negative to silver impregnation while areas with double contour of capillary loops can be observed (PAMS, 20x obj.). g and h - The deposits, on the other hand, are positive to Masson’s trichrome stain (TRI, 20x obj.). i and j - Electron microscopy shows massive electron-dense deposits in mesangium (i) and subendothelial location (j), identified by arrows (original magnification, × 3000). k and l images show abundant electron-dense deposits in mesangium and capillary loops, predominantly subendothelial but focally subepithelial in K (identified with a star) (original magnification, × 20,000 in k and × 4400 in l). m and n - In high-power view, deposits are finely granular (m - original magnification, × 250,000) and in subendothelial location (n - original magnification, × 7000). o and p - Immunohistochemistry for fibronectin revealing markedly positive giant deposits in mesangium and capillary loops (IH for fibronectin, 20x obj.)

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