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Table 1 Baseline patient profiles (n = 2272)

From: Analysis of survival after initiation of continuous renal replacement therapy in patients with extracorporeal membrane oxygenation

Variable

CRRT ≤3 days

(n = 1234)

CRRT 4–6 days

(n = 451)

CRRT ≥7 days

(n = 587)

P

Age (years)

57.7 ± 15.8

58.3 ± 16.0

57.5 ± 15.8

0.696

Age group (years)

   

0.443

 ≤ 40

190 (15.4)

62 (13.7)

94 (16.0)

 

 41–50

179 (14.5)

70 (15.5)

91 (15.5)

 

 51–60

285 (23.1)

102 (22.6)

123 (21.0)

 

 61–70

252 (20.4)

101 (22.4)

140 (23.9)

 

 71–80

256 (20.7)

85 (18.8)

96 (16.4)

 

 > 80

72 (5.8)

31 (6.9)

43 (7.3)

 

Sex

   

0.689

 Male

895 (72.5)

319 (70.7)

417 (71.0)

 

 Female

339 (27.5)

132 (29.3)

170 (29.0)

 

ECMO indication

   

0.007

 CV (cardiogenic shock, myocarditis, or AMI)

341 (27.6)

107 (23.7)

117 (19.9)a

 

 Post-cardiotomy shock

545 (44.2)

219 (48.6)

285 (48.6)

 

 Respiratory

256 (20.7)

94 (20.8)

154 (26.2)a

 

 Trauma

54 (4.4)

20 (4.4)

19 (3.2)

 

 Other

38 (3.1)

11 (2.4)

12 (2.0)

 

ECMO duration (days)

3.9 ± 4.1

5.2 ± 3.9a

7.1 ± 6.4a

< 0.001

Comorbidities

 Chronic kidney disease

152 (12.3)

62 (13.7)

81 (13.8)

0.588

 Diabetes mellitus

367 (29.7)

141 (31.3)

203 (34.6)

0.114

 Hypertension

496 (40.2)

180 (39.9)

228 (38.8)

0.858

 Heart failure

267 (21.6)

86 (19.1)

102 (17.4)

0.089

 Coronary artery disease

650 (52.7)

238 (52.8)

282 (48.0)

0.151

 Prior myocardial infarction

178 (14.4)

46 (10.2)

67 (11.4)

0.036

 Atrial fibrillation

125 (10.1)

37 (8.2)

63 (10.7)

0.371

 Peripheral arterial disease

50 (4.1)

25 (5.5)

26 (4.4)

0.421

 Prior stroke

124 (10.0)

51 (11.3)

67 (11.4)

0.596

 Chronic obstructive pulmonary disease

81 (6.6)

28 (6.2)

41 (7.0)

0.880

 Liver cirrhosis

62 (5.0)

18 (4.0)

27 (4.6)

0.668

 Malignancy

79 (6.4)

25 (5.5)

40 (6.8)

0.700

 Charlson score

2.63 ± 2.28

2.52 ± 2.17

2.65 ± 2.30

0.619

Study year

   

< 0.001

 2007–2009

412 (33.4)

124 (27.5)

149 (25.4)a

 

 2010–2011

409 (33.1)

141 (31.3)

182 (31.0)

 

 2012–2013

413 (33.5)

186 (41.2)a

256 (43.6)a

 

ECMO volume

   

0.071

 1st (1–143)

327 (26.5)

125 (27.7)

149 (25.4)

 

 2nd (149–220)

268 (21.7)

120 (26.6)

144 (24.5)

 

 3rd (230–441)

264 (21.4)

102 (22.6)

118 (20.1)

 

 4th (485–719)

375 (30.4)

104 (23.1)

176 (30.0)

 

Hospital level

   

< 0.001

 Medical center

879 (71.2)

346 (76.7)

483 (82.3)a

 

 District/regional hospital

355 (28.8)

105 (23.3)

104 (17.7)a

 

Follow-up (years)

0.36 ± 1.09

0.50 ± 1.33

0.44 ± 1.08

0.062

  1. AMI Acute myocardial infarction, CRRT Continuous renal replacement therapy, CV Cardiovascular, ECMO Extracorporeal membrane oxygenation
  2. aindicates P < 0.05 versus CRRT ≤3 days in the Bonferroni multiple comparisons